a16z Podcast

What exactly is an AI agent — and does anyone actually agree?

In this episode, taken from of AI + a16z, General Partner Guido Appenzeller and partners Matt Bornstein and Yoko Li break down one of the most hyped- and most hotly debated 0 concepts in AI right now: agents.

Are agents just clever wrappers around LLMs? Tools that can reason and act? Or simply a fresh label for familiar tech?

Whether you're building, investing, or just trying to make sense of the buzz, this episode is for you.

Resources:
Find Guido on X: https://x.com/appenz

Find Yoko on X: https://x.com/stuffyokodraws

Find Matt on X: https://x.com/BornsteinMatt

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Recorded live at the 2025 a16z LP Summit, this episode is a candid conversation between a16z cofounders Marc Andreessen and Ben Horowitz—hosted by general partner Erik Torenberg.

They cover the evolution of a16z from startup firm to multi-practice platform, how the media landscape is shaped by meme-speed narratives, why reorgs—not just returns—determine who wins, and what it takes to build an enduring venture franchise.

They also share thoughts on the changing policy landscape for AI and crypto, the firm’s bipartisan approach to Washington—and why Marc personally screens social media profiles before anyone joins the team.

Resources: 

Find Marc on X: https://x.com/pmarca

Find Ben on X: https://x.com/bhorowitz

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Follow our host: Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Business Process Outsourcing (BPO) is a $300 billion industry powering the back- and front-office operations of the world’s largest companies.

In her article, "Unbundling the BPO: How AI Will Disrupt Outsourced Work," Kimberly Tan (Partner, a16z) explores how the rise of AI is challenging the status quo. 

In this episode, Kimberly unpacks the shift—from call centers and invoice processing to cross-system automation and coding agents. They explore how AI is redefining the economics of scale, unlocking new markets, and expanding the reach of automation beyond the Fortune 500. For founders and operators alike, this conversation offers a clear-eyed look at the playbook for building in this newly addressable space.

Resources: 

Read the article: https://a16z.com/unbundling-the-bpo-how-ai-will-disrupt-outsourced-work/

Find Kimberly on X: https://x.com/kimberlywtan

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today on the a16z Podcast, we’re sharing Marc Andreessen’s recent appearance on TBPN.

Marc—cofounder and general partner at a16z—joins hosts John Coogan and Jordi Hays for a wide-ranging conversation, recorded live at the a16z’s 2025 LP Conference in Las Vegas.

They cover the rise of AI, the future of open source models, and how tech is transforming every corner of the economy—from education and defense to healthcare and housing.

Marc also shares his thoughts on the evolution of venture capital, the firm’s new branding, and what it takes to build enduring companies in a rapidly changing world.

Resources:

Watch more from TBPN: https://www.tbpn.com/

Find TBPN on X: https://x.com/tbpn

Find Marc on X: https://x.com/pmarca

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

American healthcare is in crisis—but what if we could change the system by preventing disease before it starts?

In this episode of the a16z Podcast, general partner Vijay Pande sits down with Dr. Eric Topol, founder and director of the Scripps Research Translational Institute and one of the most cited researchers in medicine, to explore the cutting edge of preventive healthcare and longevity science.

Drawing from his new book Super Agers: An Evidence-Based Path to Longevity, Topol breaks down why understanding the biology of aging—not reversing it—is the key to preventing the “Big Three” age-related diseases: cancer, cardiovascular disease, and neurodegenerative conditions. The conversation spans AI-powered risk prediction, organ clocks, polygenic risk scores, GLP-1s, and the cultural and economic shifts required to move from a “sick care” system to one rooted in precision prevention and extended healthspan.

If you’ve ever wondered how data, personalized medicine, and AI can add seven healthy years to your life—and what it will take to bring those benefits to everyone—this episode is for you.

Resources: 

Find Eric on X: https://x.com/erictopol

Find Vijay on X: https://x.com/vijaypande

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode of th a16z Podcast, we’re sharing Katherine Boyle’s recent interview on TBPN.

Katherine—General Partner at a16z and the architect of the American Dynamism thesis—joins hosts John Coogan and Jordi Hays to discuss the state of the movement today. They cover the Department of Defense’s sweeping reform efforts, the role of startups in national security, and why American Dynamism is just getting started.

From procurement reform to reindustrialization, this wide-ranging conversation explores how founders and investors are reshaping the future in service of the national interest.

Resources:

Watch more from TBPN: https://www.tbpn.com/

Find TBPN on X: https://x.com/tbpn

Find Katherine on X: https://x.com/KTmBoyle

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Your ideal customer profile (ICP) is the north star for your entire company: it determines who you’re building for and selling to. Though most growth-stage founders think they know who their ICP is, very few know how to update and refine it to keep the company focused as they grow—which can lead to a lot of headaches down the road.

In this debut episode of a16z Growth’s new company scaling podcast, the a16z Guide to Growth, a16z's Joe Morrissey (General Partner, a16z Growth), Michael King (Partner, Go-to-Market Network), and Mark Regan (Partner, a16z Growth) break down why ICP misalignment is often the hidden cause of common problems across the entire company, from pipeline gaps and bloated marketing spend to stalled product roadmaps—and dive deep on how to fix it.

They offer tactical advice for defining (and refining!) your ICP as you scale, explain why getting it right requires company-wide alignment, and how to navigate the “precision paradox” when implementing it. Plus, why ICPs matter even more in the AI era, and how a well-executed ICP shows up across the business when it's working.

Resources: 

Read more on sales and go-to-market on our Growth Content Compendium

Find Joe on LinkedIn: https://www.linkedin.com/in/morrisseyjoe/

Find Mark on LinkedIn: https://www.linkedin.com/in/mregan178/

Find Michael on LinkedIn: https://www.linkedin.com/in/michael-king-62258/

Find Emma on LinkedIn: https://www.linkedin.com/in/emmajanaskie/

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s critical infrastructure—air traffic, logistics, defense—is powered by legacy software. And that’s a problem.

In this episode, recorded live at the a16z American Dynamism Summit, a16z partner Leila Hay sits down with Phillip Buckendorf, CEO of Air Space Intelligence, and Lt. Gen. Leonard J. Kosinski (Ret.), ASI’s Chief Strategy Officer and former Director for Logistics on the Joint Staff for the Pentagon. 

They explore why software is now a weapon system, how dual-use tech can harden both civilian and military infrastructure, and what happens if we don’t modernize fast enough.

Resources:

Find Phillip on LinkedIn: https://www.linkedin.com/in/phillipbuckendorf/?locale=en_US

Find Lieutenant General Leonard J Kosinsk on LinkedIn: https://www.linkedin.com/in/ljkosinski/

Find Leila on LinkedIn: https://www.linkedin.com/in/leilahay/

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Are we nearing the end of the smartphone era?

In this episode, a16z Growth General Partner David George talks with Meta CTO Andrew “Boz” Bosworth about what comes after apps and touchscreens. From smart glasses to AR headsets, Boz shares how AI is powering a new wave of computing—one that’s ambient, agentic, and driven by human intent.

They explore what it takes to build for this future, the risks of changing interaction models, and why the next big platform shift may already be in motion.

This episode is part of our AI Revolution series, where we explore how industry leaders are leveraging generative AI to steer innovation and navigate the next major platform shift. Discover more insights and content from the AI Revolution series at a16z.com/AIRevolution.

Resources: 

Find Boz on X: https://x.com/boztank

Find David on X: https://x.com/davidgeorge8

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Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In today’s world, the battlefield extends far beyond war zones—it’s embedded in our tech stacks, supply chains, and airspace security systems. So who better to solve these modern challenges than those who’ve served on the front lines?

Recorded live at the third annual American Dynamism Summit in Washington D.C., this episode features a16z’s Matt Shortal—a veteran himself—moderating a conversation with three founders who transitioned from military service to building cutting-edge defense startups:

• John Doyle, founder & CEO of Cape 
• David Tuttle, cofounder & CEO of Rune 
• Grant Jordan, founder & CEO of SkySafe

The panel covers their journeys from service to startups, how their time in uniform shaped what they chose to build, and whether veterans should go straight into entrepreneurship—or stop first at places like Palantir or Anduril. They also discuss how Ukraine changed the game, how dual-use tech is shifting the innovation landscape, and how to instill trust and culture in mission-driven companies.

The big question: how do we win the next war—the asymmetric, fast-moving, tech-enabled kind—and build the industrial base we need to do it?

Resources: 

See more from The American Dynamism Summit 2025: www. a16z.com/american-dynamism-summit

Find John of  LinkedIn: https://www.linkedin.com/in/john-doyle-48633227/

Find David on LinkedIn: https://www.linkedin.com/in/davidtuttle1/

Find Grant on LinkedIn: https://www.linkedin.com/in/grantjordansd/

Find Matt on LinkedIn: https://www.linkedin.com/in/matthew-shortal/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

War has always been shaped by technology—from steel and gunpowder to GPS and nuclear weapons. But the decisive technologies of tomorrow aren’t coming—they’re already here.

In this episode, recorded live at our third annual American Dynamism Summit, a16z’s Senior National Security Advisor Matt Cronin sits down with Ryan Tseng (cofounder & CEO, Shield AI) and Adam Bry (cofounder & CEO, Skydio) to discuss the rise of autonomous drones, AI-driven warfare, and the escalating great power competition with China. They cover:

• Why drones are reshaping the battlefield in Ukraine, Israel, and beyond
• The asymmetry of $1,000 drones taking out $10M tanks
• Why U.S. drone production lags China—and how to catch up
• The ethical and tactical implications of autonomy in combat
• What it will take to reindustrialize America and maintain deterrence

If the future of warfare is software-defined, who writes that software—and who deploys it first—matters more than ever.

Resources: 

Find Adam on X: https://x.com/adampbry

Find Ryan on LinkedIn: https://www.linkedin.com/in/ryantseng/

Find Matt on LinkedIn: https://www.linkedin.com/in/matt-cronin-8b88811/

See more from the American Dynamism Summit: www. a16z.com/american-dynamism-summit

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

When people think about startups working with the government, the phrase “black box” often comes up. But what if that box is finally being pried open?

In this episode—recorded live at the American Dynamism Summit in DC—we talk with two Chief Technology Officers at the heart of American defense: Alex Miller, CTO for the Chief of Staff of the Army, and Justin Fanelli, CTO at the Department of the Navy. Along with a16z partner Leila Hay, they break down how the Department of Defense is shifting from decades-old processes to software-speed execution, why the real bottlenecks are cultural, not technical, and how startups can actually navigate and scale within this massive system.

From replacing outdated procurement with faster pathways, to getting tech into the hands of warfighters faster, this is a rare look inside the government’s most ambitious efforts to modernize—and what it means for builders on the outside.

Is it time to rip up the system and start fresh? Or are the seeds of change already in the ground?

Resources: 

DoD Contracts for Startups 101: https://a16z.com/dod-contracting-for-startups-101/

Find Justin on LinkedIn: https://www.linkedin.com/in/justinfanelli/

Find Leila on LinkedIn: https://www.linkedin.com/in/leilahay/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This month, a16z’s Consumer team released the fourth edition of the GenAI 100 — a data-driven ranking of the top 50 AI-first web products and mobile apps, based on unique monthly visits and active users.

In just six months, the consumer AI landscape has shifted dramatically. Some products surged ahead, others plateaued, and a few unexpected players reshaped the leaderboard entirely.

In this episode, a16z General Partner Anish Acharya and Partner Olivia Moore join us to unpack the latest rankings and explore the key cultural and product moments that brought us to this point.

Which applications are leading the pack — and which ones are quietly on the rise? What do trends like AI video, companion apps, and “vibe coding” reveal about the future of consumer AI? And for the first time, the team also analyzed which products aren’t just gaining users, but generating real revenue.

If you’re looking to understand where we are in the GenAI adoption cycle — and what might come next — this episode offers a data-backed view into one of the fastest-moving corners of technology.

You can find the full GenAI 100 list at a16z.com/genai100-4

Timecodes: 

00:00: Consumer AI Trends

00:36: The Gen AI 100 List: Methodology and Insights

02:38: Pivotal Moments in AI Development

05:37: Assumptions and Realities in AI

08:49: Emerging Trends and Newcomers

11:53: The Brink List: Near Misses and Future Contenders

16:13: Surprises and Consistencies in AI Adoption

18:31: The Future of AI Applications

19:54: Traffic Trends and User Demographics

20:32: Resurgence and New Use Cases

22:47: Competitors and Market Dynamics

25:30: AI Video Models and Trends

29:23: Mobile vs Desktop Usage

30:34: Revenue Insights and Monetization

34:06: Key Learnings and Final Thoughts

Resources: 
Find Anish on X: https://x.com/illscience

Find Olivia on X: https://x.com/omooretweets

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The global race for AI leadership is no longer just about companies—it’s about nations. AI isn’t just computing infrastructure; it’s cultural infrastructure, economic strategy, and national security all rolled into one.

In this episode, Jensen Huang, founder and CEO of NVIDIA, and Arthur Mensch, cofounder and CEO of Mistral, sit down to discuss sovereign AI, national AI strategies, and why every country must take ownership of its digital intelligence.

• How AI will reshape global economies and GDP
• The full AI stack—from chips to models to AI factories
• Why AI is both a general purpose technology and deeply specialized
• The open-source vs. closed AI debate and its impact on sovereignty
• Why no one will build AI for you—you have to do it yourself

Is this the most consequential technology shift of all time? If so, the stakes have never been higher.

Resources: 

Find Arthur on X: https://x.com/arthurmensch

Find Anjney on X: https://www.linkedin.com/in/anjney/

Find NVIDIA on X: https://x.com/nvidia

Find Mistral: https://x.com/MistralAI

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

AI voice technology has been around for years — think Siri or Alexa — but the magic has been missing. That’s changing, and quickly!

In this episode, Anish Acharya, General Partner at a16z, and Olivia Moore, Partner at a16z, explore why AI voice is reaching a breakthrough moment, how today’s models feel more human than ever, and why voice is poised to become the primary way people interact with AI.

With businesses already making tens of thousands of AI-driven phone calls daily, AI-powered conversations are no longer a distant vision—they’re happening now. Whether it's AI companions, customer service bots, or enterprise applications, voice tech is here—and it’s improving faster than anyone expected.

Resources:

Find Anish on X: https://x.com/illscience

Find Olivia on X: https://x.com/omooretweets
Read the report: https://a16z.com/ai-voice-agents-2025-update/

Listen to Raising Health’s episode on how voice AI is solving healthcare’s workforce challenges : https://a16z.com/podcast/voice-ai-solving-healthcares-workforce-challenges-with-ankit-jain/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

For over a century, the United States has been the birthplace of world-changing innovation – from the Wright brothers’ first flight to the invention of the transistor, the moon landing, and the birth of the internet. But in recent years, belief in American progress has wavered.

Three years ago, a16z General Partner Katherine Boyle wrote a bold thesis called Building American Dynamism, challenging this apathy and calling for startups to tackle the country’s biggest problems. The idea spread fast – first as a meme, then as a movement, and today as a $600M dedicated fund.

In this episode, Katherine and fellow a16z General Partner David Ulevitch discuss:

• The origins of American Dynamism—and why it was controversial at first
• How Washington and Silicon Valley can come together
• America’s competitiveness in today’s great power competition
• The latest American Dynamism 50 list focused on the Indo-Pacific, showcasing the top startups building for the national interest

If you’re curious about the future of America, this is a conversation you won’t want to miss.

Check out this year’s full AD50 list at a16z.com/AD50.

Resources: 

Find David on X: https://x.com/davidu

Find Katherine on X: https://x.com/KTmBoyle

Find last year’s’ American Dynamism 50 AI Addition’ here: https://a16z.com/american-dynamism-50-ai/

Read Katherine’s article ‘Building American Dynamism’: https://a16z.com/building-american-dynamism/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Henry Ward, cofounder and CEO of Carta, has spent over a decade scaling his company from an early-stage startup to a 2,000-person industry leader. In this a16z Speedrun conversation with Games partner Josh Lu, Henry shares hard-earned lessons on:

• Hiring missionaries vs. mercenaries — and how to keep company culture intact as you scale
• The reality of product-market fit and why many founders try to sell too soon
• The evolution of a CEO — from building a product to building a system around you
• Inputs vs. outputs, and why companies should focus on the right leading indicators
• Transparency in leadership, including when (and when not) to share

This episode is packed with candid insights and lessons on company building. Recorded live at the a16z Speedrun program, you can learn more at a16z.com/games/speedrun.

Resources: 

Find Henry on X: https://x.com/henrysward

Find Josh on X: https://x.com/JoshLu

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Being a creator in 2025 is tough—but building for creators is even harder. Perhaps no one understands this conundrum better than Scott Belsky. As the founder of Behance, a longtime executive at Adobe, and an advisor to companies like Pinterest and Atlassian, Scott has spent his career at the intersection of technology, design, and creativity.

In this speedrun episode, recorded live in San Francisco during the fourth iteration of our a16z Games Speedrun program, we dive into:

• How AI can actually enable creators—and where its toolset should end
• The evolution from the "prompt era" to the "controls era" of AI
• Whether people really want bespoke, personalized experiences or simply crave familiarity
• What happens when creative scarcity disappears and AI-generated content becomes ubiquitous
• The future of creative tooling, from generative UI to AI-native interfaces

Plus, Scott shares insights from his time building Behance, leading product strategy at Adobe, and investing in the next generation of creative tools.

If you want to learn more about A16Z Games Speedrun, visit a16z.com/games/speedrun.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Technology doesn’t grow in isolation—it evolves in waves. Just as mobile, cloud, and SaaS shaped the internet of the past 20 years, so too could crypto, AI, and new hardware usher in an era of the internet that’s pro-innovation, pro-startup, and pro-creator. 

Speaking with a16z Growth General Partner David George, a16z crypto Founder and Managing Partner Chris Dixon breaks down his vision for a new internet, from using crypto to decentralize AI infrastructure and kickstart network effects, to why AI will be this era’s native form of media just as film was in the 1930s. He also explores why the internet’s original covenant—where content creators traded free access for search traffic—is breaking today, and how a better internet could introduce entirely new business models for creators. 

Right now, we have a choice to make: will the next era of the internet be shaped by a handful of centralized players, or transformed into an open ecosystem where power and control flow to creators across the globe?

Resources:

Watch the conversation here: https://youtu.be/gioxu1CVjhM  

Read more, including the full transcript, here: https://a16z.com/ai-crypto-internet-chris-dixon/

Chris’s recent article on blockchain innovation: https://a16zcrypto.com/posts/article/blockchain-ai-internet/

Find Chris’s book, Read Write Own: Building the Next Era of the Internet:

Penguin Random House: https://www.penguinrandomhouse.com/books/744504/read-write-own-by-chris-dixon/

Penguin UK: https://www.penguin.co.uk/books/459860/read-write-own-by-dixon-chris/9781804949245

For more resources on AI & crypto visit: https://a16zcrypto.com/posts/?tag=ai-crypto,web2-to-web3

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Critical materials like copper, lithium, and gallium have been mined for decades, but their role in core technologies, geopolitics, and the energy transition have come to a height in recent years.

In this episode, a16z partner Connie Chan discusses how technology is changing the game of  identification and exploration, together with leading company KoBold and their VP of Geoscience, VP of Technology, and CEO of Africa.

Resources:

Learn more about KoBold Metals: https://www.koboldmetals.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Two words have caught the Internet by storm. DeepSeek. 

The Chinese reasoning model r1 is rivaling others at the frontier with an open-source MIT license, methods that some claim may be 45x more efficient, an alleged $5.6m cost, the release of reasoning traces, a follow-on image model, and the fact that all of this was released by a hedge fund China.

Many are already referring to this as a Sputnik moment. If that’s true, how should we – whether founder, researcher, policy maker – not just react, but act? Joining us to tease out the signal from the noise are a16z General Partner Martin Casado and a16z board partner, Steven Sinofsky. Both Martin and Steven have been on the frontlines of prior computing cycles, from the switching wars to the fiber buildout, and have witnessed the trajectories of companies like Cisco to AOL to ATT – even Worldcom.

So what really drove this DeepSeek frenzy and more importantly what should we take away? Today, we answer that question through the lens of Internet history.

Resources:

• Steven’s article: DeepSeek Has Been Inevitable and Here's Why (History Tells Us)
• Alex Rampell’s article: Why DeepSeek Is a Gift to the American People

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This week, a16z cofounder Ben Horowitz had a rare and invaluable conversation with Dr. Clarence B. Jones, a pivotal figure in American history. 

Dr. Jones, who served as speechwriter, attorney, and advisor to Dr. Martin Luther King Jr., shared his personal insights on race, inclusion, and the lasting legacy of the civil rights movement in 2025.

In their wide-ranging discussion, Dr. Jones reflected on the timeless wisdom of Dr. King, quoting one of the most enduring lines from the "I Have a Dream" speech: “I want my four children to be judged by the content of their character, not by the color of their skin.”

“That, to me, is still, that’s the template,” Dr. Jones said. “That still remains a template.”

Their conversation covered critical themes in Diversity, Equity, and Inclusion, delving into the history of the movement, the lessons from "Letter from Birmingham Jail," and the profound impact Dr. King’s work continues to have today.

It was a rare opportunity to hear directly from someone who not only witnessed history but played a key role in shaping it, and we hope you enjoy it.

About Dr. Clarence B. Jones:

Dr. Clarence B. Jones served as legal counsel, strategic advisor, and draft speechwriter to Dr. Martin Luther King, Jr. from 1960 until Dr. King’s assassination in Memphis, Tennessee, on April 4, 1968. During that time, Dr. King depended on Dr. Jones for legal and strategic counsel and assistance in drafting landmark speeches and public testimony. He is credited with writing the first seven paragraphs of the iconic I Have A Dream speech. 

Across the decades following Dr. King’s assassination in 1968, Clarence B. Jones worked to carry on Dr. King’s legacy, to continue the nonviolent struggle for social justice, voting rights, and democratic inclusion. He is the founder of the Dr. Clarence B. Jones Institute for Social Advocacy, and also serves as the Founding Director Emeritus of the Institute for Nonviolence and Social Justice at the University of San Francisco. Dr. Jones is also the author of three acclaimed books "What Would Martin Say?", "Behind the Dream: The Making of the Speech that Transformed a Nation" and "Last of the Lions".

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Ben on X:  http://twitter.com/bhorowitz

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

How is AI reshaping modern warfare? 

Speaking with a16z Growth General Partner David George, Anduril cofounder and CEO Brian Schimpf discusses how AI helps humans make better strategic decisions by sorting through the enormous amount of data collected from modern battlefields. Schimpf also discusses navigating the US government’s complex procurement processes, using commercial technologies to kickstart their own product development, and the growing opportunities for startups in defense. Throughout, Brian offers a deep dive into the intersection of technology, geopolitics, and the future of defense.

This episode is part of our AI Revolution series, where we explore how industry leaders are leveraging generative AI to steer innovation and navigate the next major platform shift. Discover more insights and content from the AI Revolution series at a16z.com/AIRevolution.

Resources: 

Find Brian on X: https://x.com/schimpfbrian

Find David on X: https://x.com/davidgeorge83

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shift from rigid RPA systems to AI-powered agents and why this evolution unlocks massive opportunities in legacy markets.

Drawing on her article "RIP to RPA: The Rise of Intelligent Automation," Kimberly shares real-world examples of companies revolutionizing referral management, and highlights how startups can build impactful solutions in this space.

Resources:

Find Kimberly on X: https://x.com/kimberlywtan

Read Kimberly’s article: https://a16z.com/rip-to-rpa-the-rise-of-intelligent-automation/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why is this the case, and what will it take to fix it?

In this episode, a16z cofounder Marc Andreessen and General Partners Vijay Pande and Julie Yoo tackle some of the biggest questions shaping the future of healthcare:

• Is the solution to our healthcare crisis a policy, technology, or competition problem?
• Will AI and technology transform the industry, or are regulatory and structural barriers too entrenched?
• Who will crack the code—healthcare incumbents, tech giants, or AI-native startups?

From chronic care to cost curves, from disruptive technologies to shifting patient agency, this conversation offers an unfiltered look at what’s broken in the healthcare system and how it might finally change.

Resources: 

Find Marc on X: https://x.com/pmarca

Find Vijay on X: https://x.com/vijaypande

Find Julie on X: https://x.com/julesyoo

The Biggest Company in the World

Why Will Healthcare be the Industry that Benefits Most from AI?

Grand Challenges in Healthcare AI with Vijay Pande and Julie Yoo

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode, Substack cofounder and CEO Chris Best joins a16z General Partner Andrew Chen to discuss the origins and evolution of Substack, a platform redefining media and empowering creators to connect directly with their audiences. They dive into how Substack’s early days led to over 3 million paid subscribers, why creators are moving away from traditional platforms to establish direct connections with their audiences, and how the future of media in the AI era is reshaping opportunities for writers, podcasters, and video creators.

From Chris’s lessons scaling Kik Messaging to Substack’s profound impact on the creator economy, this conversation shares insights on building platforms, culture, and opportunity in the modern era.

Resources: 

Find Chris on Substack: https://cb.substack.com/

Find Andrew Chen on Substack: https://andrewchen.substack.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90

Welcome to our special end-of-year episodes -- which also look ahead to 2025 --  covering our annual Big Ideas lists, where various a16z crypto team members share what they are personally excited about. (You can see the firmwide list, also including all the trends of the crypto team,  here.)

This episode is part 1 of 2 -- but you don't have to listen to them in any particular order -- covering the trends and themes of:

• stablecoins, payments, and where the early adopters will come from;
• app store distribution, curation, and discovery;
• where the next crypto users will come from, turning passive holders into active users;
• how builders improve, and better choose, infrastructure; and
• simplifying user experience.

 Covering each of these -- and coming from the investing, go-to-market, data science, research, and media teams are:  Sam Broner, Maggie Hsu, Daren Matsuoka, Joachim Neu, and Chris Lyons; in conversation with hosts Sonal Chokshi and Robert Hackett. (Stay tuned until the end for some of our meta-commentary.) 

These are just 5 of the 14 trends we shared; you can check out the full list at a16zcrypto.com/bigideas.

Also be sure to check out part 2, which covers all the trends at the intersection of crypto and AI. 

As a reminder, none of the content is investment, business, legal, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.

As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.

 In this episode, a16z General Partners Julie Yoo and Angela Strange, and Partner Joe Schmidt, dive into the transformative power of AI across healthcare, fintech, and traditional service sectors.

We explore:

• Super Staffing for Healthcare: How AI can address critical clinical labor shortages and augment care delivery at scale.
• Regulation Becomes Code: The potential for AI to simplify and streamline compliance, making systems safer and more efficient.
• Romanticizing Inorganic Growth: The opportunity for AI-powered startups to redefine service industries through workflow automation and strategic acquisition.

With insights from a16z’s Bio + Health, Fintech, and Apps teams, this episode unpacks the ideas that will revolutionize traditional systems and unlock opportunities in 2025.

Check out the full 50 Big Ideas for 2025 at a16z.com/bigideas.

Resources: 

Find Angela on X: https://x.com/astrange

Find Julie on X: https://x.com/julesyoo

Find Joe on X: https://x.com/joeschmidtiv

Link to article 'The Messy Inbox Problem: Wedge Strategies in AI Apps': https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI race is on, and 2025 could be its most transformative year yet.

In this episode, a16z General Partners Anjney Midha and Jennifer Li, and Partner Alex Immerman dive into the trends reshaping AI and its impact on search, infrastructure, and devices.

We explore:

• How AI-native tools like ChatGPT and Perplexity are challenging Google’s search dominance.
• The rise of infrastructure independence as governments prioritize compute, energy, and data.
• The future of smaller, on-device AI models driving privacy, performance, and new consumer applications.

With insights from a16z’s Growth and Infrastructure teams, this episode unpacks the forces driving AI innovation—and the opportunities founders and nations could seize to lead in the next wave of technology.

Stay tuned for more in this four-part series, and explore the full 50 Big Ideas for 2025 at a16z.com/bigideas.

Resources: 

Find Alex on X: https://x.com/aleximm

FInd Anjney on X: https://x.com/AnjneyMidha

FInd Jennifer on X: https://x.com/JenniferHli

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we design, train, and innovate across sectors.

In this episode, a16z General Partner Erin Price-Wright, Engineering Fellow Millen Anand, and Partner Troy Kirwin discuss the trends reshaping the future of hardware, software, and beyond.

We explore:

• How robots and full-stack engineers are driving the next industrial renaissance.
• The explosion of Earth observation data and its potential to revolutionize industries.
• How gaming technology is moving beyond entertainment to reshape training, design, and more.

This is just the beginning of our four-part series on 50 Big Ideas for 2025—don’t miss the full list at a16z.com/bigideas.

Resources: 

Find Erin on X: https://x.com/espricewright

Find Millen on LinkedIn: https://www.linkedin.com/in/millen-anand/

Find Troy on X: https://x.com/tkexpress11

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke joins a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit.

Together, they explore what it takes to build a breakout startup in a competitive market, the changing landscape of retail, and how to drive workplace change while navigating corporate culture and calls for activism.

Tobias shares the story behind Shopify's growth from a snowboarding store to a global ecommerce platform serving millions of merchants, discusses the moral imperative of creating great software, and offers insights on leadership, innovation, and embracing negativity as a tool for progress.

The episode also touches on the intersection of AI and crypto, the power of decentralization, and the next wave of technologies reshaping business and commerce.

Resources:

Find Ben on X: https://x.com/bhorowitz

Find Toni on X: https://x.com/tobi

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero?

In this episode General Partners Alex Rampell, David Haber, and Angela Strange discuss how AI is revolutionizing labor by automating tasks traditionally done by humans.

They’ll trace the evolution of cloud eras — from the original to financial services-enabled to the current AI-enabled outcomes era — showcasing how AI is creating unprecedented opportunities, allowing startups to outpace incumbents. They also explore how this shift will reshape industries, where we are in the adoption curve and what companies need to succeed, and the gaps where the a16z Enterprise team would love to see more innovation.

Resources:

• AI Turns Capital to Labor:  https://a16z.com/ai-turns-capital-to-labor/
• The Messy Inbox Problem: https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies/
• Vertical SaaS: Now with AI Inside: https://a16z.com/vertical-saas-now-with-ai-inside/
• BarbAIrians at the Gate: The Financial Opportunity of AI: https://a16z.com/financial-opportunity-of-ai/

Stay Updated:

• Let us know what you think: https://ratethispodcast.com/a16z
• Find a16z on Twitter: https://twitter.com/a16z
• Find a16z on LinkedIn: https://www.linkedin.com/company/a16z
• Subscribe on your favorite podcast app: https://a16z.simplecast.com/
• Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.a

Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue to lag. Why?

In this episode, we dive into the systemic issues—misaligned incentives, political resistance, and the lack of a shared vision around the purchase of an education. We also explore how technology and entrepreneurial innovation may be shifting the tide.

You’ll hear from Anurupa Ganguly (Prisms), Chris Bennett (Wonderschool), Anna Edwards (Whiteboard Advisors), and a16z General Partner Jeff Jordan discuss the criticality of early childhood education, how public-private partnerships are required for scale, and how we can engage risk-averse decision-makers. 

Listen to learn how the next generation can reclaim the American dream.

Resources: 

Find Jeff on Twitter: https://x.com/jeff_jordan

Find Chris on Twitter: https://x.com/8ennett

Find Anna on LinkedIn: https://www.linkedin.com/in/annakimseyedwards/

Find Anurupa on Twitter: https://x.com/aganguly26

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This episode was originally published on our sister podcast, web3 with a16z. If you’re excited about the next generation of the internet, check out the show: https://link.chtbl.com/hrr_h-XC

We've heard a lot about the premise and the promise of prediction markets for a long time, but they finally hit the main stage with the most recent election. So what worked (and didn't) this time? Are they really better than pollsters, is polling dead? 

So in this conversation, we tease apart the hype from the reality of prediction markets, from the recent election to market foundations... going more deeply into the how, why, and where these markets work. We also discuss the design challenges and opportunities (including implications for builders throughout). And we also cover other information aggregation mechanisms -- from peer prediction to others -- given that prediction markets are part of a broader category of information-elicitation and information-aggregation mechanisms. 

Where do domain experts, superforecasters, pollsters, and journalists come in (and out)? Where do (and don't) blockchain and crypto technologies come in -- and what specific features (decentralization, transparency, real-time, open source, etc.) matter most, and in what contexts?  Finally, we discuss applications for prediction and decision markets -- things we could do right away to in the near-future to sci-fi -- touching on trends like futarchy, AI entering the market, DeSci, and more.  

Our special expert guests are Alex Taborrok, professor of economics at George Mason University and Chair in Economics at the Mercatus Center; and Scott Duke Kominers, research partner at a16z crypto, and professor at Harvard Business School  -- both in conversation with Sonal Chokshi. 

As a reminder: None of the following should be taken as business, investment, legal, or tax advice; please see a16z.com/disclosures for more important information. 

Resources:
(from links to research mentioned to more on the topics discussed)

• The Use of Knowledge in Society by Friedrich Hayek (American Economic Review, 1945)
• Everything is priced in by rsd99 (r/wallstreetbets, 2019)
• Idea Futures (aka prediction markets, information markets) by Robin Hanson (1996)
• Auctions: The Social Construction of Value  by Charles Smith
• Social value of public information by Stephen Morris and Hyun Song Shin (American Economic Review, December 2002)
• Using prediction markets to estimate the reproducibility of scientific research by Anna Dreber, Thomas Pfeiffer, Johan Almenberg, Siri Isaksson, Brad Wilson, Yiling Chen, Brian Nosek, and Magnus Johannesson (Proceedings of the National Academy of Sciences (November 2015)
• A solution to the single-question crowd wisdom problem by Dražen Prelec, Sebastian Seung, and John McCoy (Nature, January 2017)
• Targeting high ability entrepreneurs using community information: Mechanism design in the field by Reshmaan Hussam, Natalia Rigol, and Benjamin Roth (American Economic Review, March 2022)
• Information aggregation mechanisms: concept, design, and implementation for a sales forecasting problem by Charles Plott and Kay-Yut Chen, Hewlett Packard Laboratories (March 2002)
• If I had a million [on deciding to dump the CEO or not] by Robin Hanson (2008)
• Futarchy: Vote values, but bet beliefs by Robin Hanson (2013)
• From prediction markets to info finance by Vitalik Buterin (November 2024)
• Composability is innovation by Linda Xie (June 2021)
• Composability is to software as compounding interest is to finance by Chris Dixon (October 2021)
• resources & research on DAOs, a16z crypto

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and qualification, enabling sales teams to focus on high-value work—while AI provides live coaching and drives decisions across sales, marketing, and product teams.

In this episode, a16z partners Joe Schmidt and Marc Andrusko explore the evolution of sales tools and strategies, sharing their insights on what’s driving this shift.

Is this the “Death of a Salesforce”? Perhaps that’s an overstatement. But one thing is clear: the future belongs to those who leverage data and AI to drive decisions—not just activities.

Resources:

Find Marc Andrusko on X: https://x.com/mandrusko1

Find Joe Schmidt on X: https://x.com/joeschmidtiv

Read the original article: https://a16z.com/ai-transforms-sales/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What if the biggest challenge of our time isn’t living longer, but living better? 

In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul. 

We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society. 

Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.

Resources: 

Find Andrew on X: https://x.com/profandrewscott?lang=en

Find Vijay on X: https://x.com/vijaypande

Learn more about The Longevity Imperative:

https://profandrewjscott.com/the-longevity-imperative/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castelion) on why we need to revive our industrial base — and fast.

From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.

Resources:

Find Chris on X: https://x.com/2112Power

Find Jordan on X: https://x.com/jordan__black

Find Bryon on X: https://x.com/hargsb

Find Oliver on X: https://x.com/oyhsu

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2024 has been a milestone year for autonomous tech. 

Waymo’s fully autonomous driver has surpassed 20 million miles, while FAA approvals now allow commercial drones to fly without visual observers, advancing air autonomy in unprecedented ways.

In this special live recording from SF Tech Week, a16z partner Erin Price-Wright moderates a panel of experts from three key domains—air, land, and sea—to explore the latest real-world deployments of autonomous systems, the impact of new chips on cost and efficiency, building full-stack solutions, managing risk, and the evolving role of regulation in driving these technologies forward.

Joining the conversation is Macario Namie, CMO of Skydio, discussing the transition from consumer drones to enterprise and government use; Vijay Patnaik, Head of Product at Applied Intuition, who shares insights on developer tools and software for autonomous vehicles; and Peter Bowman-Davis, engineering fellow at a16z, diving into maritime autonomy based on his work at Saronic.

Resources: 

Find Macario on LinkedIn: https://www.linkedin.com/in/macario-namie-bb529/

Find Vijay on LinkedIn: https://www.linkedin.com/in/vijaysaipatnaik/

Find Peter on LinkedIn: https://www.linkedin.com/in/peter-bowman-davis/

Find Erin on Twitter: https://x.com/espricewright

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

We take you behind the scenes of our newly released, annual State of Crypto Report — a16z crypto's analysis of the latest data and trends that have defined the industry in 2024. 

This year's report features some brand new insights, from estimating the number of real crypto users globally, to understanding how much interest in crypto swing states may have ahead of the U.S. election. We also dig into infrastructure improvements to blockchains and key applications — including stablecoins, AI, and so-called DePIN. Be sure to visit a16zcrypto.com for all this and more including a new “Builder Energy” dashboard, which we’ll discuss on the show.

Joining me to talk about the findings are lead data scientist and report author Daren Matsuoka and CTO Eddy Lazzarin. The first voice you'll hear after mine is Daren's, then Eddy's.

a16z crypto resources:

-State of Crypto Report 2024

-Builder Energy dashboard

-Estimating the number of real crypto users

 by Daren Matsuoka and Eddy Lazzarin

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What does Rich Sutton’s "Bitter Lesson" reveal about the decisions Tesla is making in its pursuit of autonomy?

In this episode, we dive into Tesla’s recent "We, Robot" event, where they unveiled bold plans for the unsupervised full-self-driving Cybercab, Robovan, and Optimus—their humanoid robot, which Elon Musk predicts could become “the biggest product ever.”

Joined by a16z partners Anjney Midha and Erin Price-Wright, we explore how these announcements reflect the evolving intersection of hardware and software. We’ll unpack the layers of the autonomy stack, the sources of data powering it, and the challenges involved in making these technologies a reality.

Anjney, with his experience in computer vision and multiplayer tech at Ubiquity6, and Erin, an AI expert focused on the physical world, share their unique perspectives on how these advancements could extend far beyond the consumer market.

For more insights, check out Erin’s articles linked below. 

Resources: 

Find Anj on Twitter: https://x.com/anjneymidha

Find Erin on Twitter: https://x.com/espricewright

Read Erin’s article ‘A Software-Driven Autonomy Stack Is Taking Shape’: https://a16z.com/a-software-driven-autonomy-stack-is-taking-shape/

AI for the Physical World: https://a16z.com/ai-for-the-physical-world/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2024, marking 10 years since its launch, Apple Pay now boasts hundreds of millions of consumers in 78 markets, at checkout on millions of websites and apps, in tens of millions of stores worldwide, and is supported by more than 11,000 bank and network partners.

In this episode, a16z General Partner Alex Rampell sits down with Jennifer Bailey, VP of Apple Pay and Apple Wallet, to explore how Apple has transformed digital payments. 

Jennifer reveals how Apple Pay and Apple Wallet have grown beyond payments to include transit cards, car keys, and more. They also discuss the challenges of driving adoption, the future of digital wallets, and Jennifer’s insights for entrepreneurs.

Resources: 

Find Jennifer on LinkedIn: https://www.linkedin.com/in/jbaileyz

Find Alex on X: https://x.com/arampell

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Lisa Su has transformed AMD into a global leader in AI and high-performance computing.

In this episode of the AI Revolution (AIR) series , Bob Swan, a16z Operating Partner and former CEO of Intel, sits down with Lisa Su, CEO of AMD, to discuss how her leadership has propelled AMD’s growth and positioned the company at the forefront of AI innovation.

They explore AMD’s pivotal role in democratizing the benefits of gen AI, the evolution of AI computing, and the importance of open ecosystems and partnerships in driving technological breakthroughs.

Resources: 

Find Lisa on X: https://x.com/lisasu

Find Bob on X: https://x.com/bobswan

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Deepfakes—AI-generated fake videos and voices—have become a widespread concern across politics, social media, and more. As they become easier to create, the threat grows. But so do the tools to detect them.

In this episode, Vijay Balasubramaniyan, cofounder and CEO of Pindrop, joins a16z’s Martin Casado to discuss how deepfakes work, how easily they can be made, and what defenses we have. They’ll also explore the role of policy and regulation in this rapidly changing space.

Have we lost control of the truth? Listen to find out.

Resources:

Find Vijay on Twitter: https://x.com/vijay_voice

Find Martin on Twitter: https://x.com/martin_casado

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Last week was another big week in technology. 

Google’s NotebookLM introduced its Audio Overview feature, enabling users to create customizable podcasts in over 35 languages. OpenAI followed with their real-time speech-to-speech API, making voice integration easier for developers, while Pika’s 1.5 model made waves in the AI world.

In this episode, we chat with the a16z Consumer team—Anish Acharya, Olivia Moore, and Bryan Kim—about the rise of voice technology, the latest AI breakthroughs, and what it takes to capture attention in 2024. Anish shares why he believes this could finally be the year of voice tech.

Resources: 

Find Olivia on Twitter: https://x.com/omooretweets

Find Anish on Twitter: https://x.com/illscience

Find Bryan on Twitter: https://x.com/kirbyman01

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 1995, just 2% of couples met online. Today, that number has surged to over 50%, making online dating the top way couples connect.

In this episode, a16z General Partner Andrew Chen chats with Tinder founder Sean Rad about how he built an app that changed culture. Sean shares why seamless experiences matter, how startups often get marketing wrong, and how Tinder became the catalyst for online dating's explosive growth.

This conversation was recorded live in LA at a16z’s Games third Speedrun program. Learn more about Speedrun: https://a16z.com/games/speedrun/

Find Sean on Twitter: https://x.com/seanrad

Find Andrew on Twitter: https://x.com/andrewchen

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What if the key to unlocking AI's full potential lies not just in algorithms or compute, but in data? 

In this episode, a16z General Partner David George sits down with Alex Wang, founder and CEO of Scale AI, to discuss the crucial role of "frontier data" in advancing artificial intelligence. From fueling breakthroughs with complex datasets to navigating the challenges of scaling AI models, Alex shares his insights on the current state of the industry and his forecast on the road to AGI.

Resources: 

Find Alex on Twitter: https://x.com/alexandr_wang

Find David on Twitter : https://x.com/DavidGeorge83

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, our guests have long been laying the groundwork for innovations that are transforming industries today.

In this episode, a16z General Partner Martin Casado joins Fei-Fei and Justin to explore the journey from early AI winters to the rise of deep learning and the rapid expansion of multimodal AI. From foundational advancements like ImageNet to the cutting-edge realm of spatial intelligence, Fei-Fei and Justin share the breakthroughs that have shaped the AI landscape and reveal what's next for innovation at World Labs.

If you're curious about how AI is evolving beyond language models and into a new realm of 3D, generative worlds, this episode is a must-listen.

Resources: 

Learn more about World Labs: https://www.worldlabs.ai

Find Fei-Fei on Twitter: https://x.com/drfeifei

Find Justin on Twitter: https://x.com/jcjohnss

Find Martin on Twitter: https://x.com/martin_casado

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This week in consumer tech: Apple’s big reveals, OpenAI’s multi-step reasoning, and Adobe Firefly’s video model.

Olivia Moore and Justine Moore, Partners on the a16z Consumer team, break down the latest announcements and how these product launches will shape the tech ecosystem, transform AI-powered experiences, and impact startups competing for attention in a fast-moving market.

Resources: 

Find Justine of Twitter: https://x.com/venturetwins

Find Olivia on Twitter: https://x.com/omooretweets

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Vijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today.

The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst for value-based care, and the opportunity for innovation in clinical trials. They also talk about the AI startup they each wish would walk through the door. 

Resources: 

Find Vijay on Twitter: https://x.com/vijaypande

FInd Julie on Twitter: https://x.com/julesyoo

Listen to more episode from Raising Health: https://a16z.com/podcasts/raising-health/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @NoahRFeldman, @ahall_research, @rhhackett

Welcome to web3 with a16z. I'm Robert Hackett and today we have a special episode about governance in many forms — from nation states to corporate boards to internet services and beyond.

Our special guests are Noah Feldman, constitutional law scholar at Harvard who also architected the Meta oversight board (among many other things); he is also the author of several books. And our other special guest is Andy Hall, professor of political science at Stanford who is an advisor of a16z crypto research — and who also co-authored several papers and posts about web3 as a laboratory for designing and testing new political systems, including new work we'll link to in the shownotes.

Our hallway style conversation covers technologies and approaches to governance, from constitutions to crypto/ blockchains and DAOs. As such we also discuss content moderation and community standards; best practices for citizens assemblies; courts vs. legislatures; and much more where governance comes up. 

Throughout, we reference the history and evolution of democracy — from Ancient Greece to the present day — as well as examples of governance from big companies like Meta, to startups like Anthropic.

Resources for references in this episode:

• On the U.S. Supreme Court case NetChoice, LLC v. Paxton (Scotusblog)
• On Meta's oversight board (Oversightboard.com)
• On Anthropic's long term benefit trust (Anthropic, September 2023)
• On "Boaty McBoatface" winning a boat-naming poll (Guardian, April 2016)
• On Athenian democracy (World History Encyclopedia, April 2018)
• The Three Lives of James Madison: Genius, Partisan, President by Noah Feldman (Random House, October 2017)

A selection of recent posts and papers by Andrew Hall:

• The web3 governance lab: Using DAOs to study political institutions and behavior at scale by Andrew Hall and Eliza Oak (a16z crypto, June 2024)
• DAO research: A roadmap for experimenting with governance by Andrew Hall and Eliza Oak (a16z crypto, June 2024)
• The effects of retroactive rewards on participating in online governance by Andrew Hall and Eliza Oak (a16z crypto, June 2024)
• Lightspeed Democracy: What web3 organizations can learn from the history of governance by Andrew Hall and Porter Smith (a16z crypto, June 2023)
• What Kinds of Incentives Encourage Participation in Democracy? Evidence from a Massive Online Governance Experiment by Andrew Hall and Eliza Oak (working paper, November 2023)
• Bringing decentralized governance to tech platforms with Andrew Hall (a16z crypto Youtube, July 2022)
• The evolution of decentralized governance with Andrew Hall (a16z crypto Youtube, July 2022)
• Toppling the Internet’s Accidental Monarchs: How to Design web3 Platform Governance by Porter Smith and Andrew Hall (a16z crypto, October 2022)
• Paying People to Participate in Governance by Ethan Bueno de Mesquita and Andrew Hall (a16z crypto, November 2022)

As a reminder: none of the following should be taken as tax, business, legal, or investment advice. See a16zcrypto.com/disclosures for more important information, including a link to a list of our investments.

Half of prescribed medications are never taken, and 88% of Americans are metabolically unhealthy. Despite spending 20% of our GDP on healthcare—twice that of any other developed nation—our outcomes still lag behind.

In this episode, we explore why technologists must step into the healthcare ring. Solving medicine isn’t enough; we need to make healthcare a consumer-focused industry. a16z’s Vijay Pandey and Daisy Wolf discuss the rise of tech founders in healthcare, the potential of AI to transform patient care, and how this shift could lead to the next trillion-dollar company.

Can tech truly disrupt this complex, regulated industry?

Resources: 

Read the article ‘It’s Time to Build in Healthcare’: https://a16z.com/hey-tech-its-time-to-build-in-healthcare/

Find Vijay on Twitter: https://x.com/vijaypande

Find Daisy on Twitter: https://x.com/daisydwolf

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Latin America is emerging as a tech powerhouse, but it's not a one-size-fits-all market. 

In this episode, we explore why what works in Argentina won’t necessarily fly in Brazil or Mexico, and how companies are adapting to these unique regional dynamics. Join Dileep Thazhmon, Cofounder and CEO of Jeeves; Santiago Suarez, Cofounder and CEO of Addi; Gabriel Vasquez, a16z investment partner; and Angela Strange, a16z General Partner, as they discuss the future of fintech in LatAm and the unique approach required to succeed in this diverse market.

​​Whether you're interested in the nuances of product development, the complexities of scaling across diverse markets, or the future of fintech in Latin America, this episode offers perspectives from industry leaders deeply invested in the region's tech ecosystem who believe the next big tech giants might just come from Latin America.

Resources: 

Find Dileep on Twitter: https://x.com/thazhmon

Find Santiago on Twitter: https://x.com/santiasua

Find Gabriel on Twitter: https://x.com/gevs94

Find Angela on Twitter: https://x.com/astrange

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode, we cover the recent data breach of nearly 3B records, including a significant number of social security numbers. Joining us to discuss are security experts Joel de la Garza and Naftali Harris. Incredibly enough, Naftali and his team were able to get their hands on the breached dataset and were able to validate the nature of the claims. Listen in as we explore the who, what, when, where, why… but also how a breach of this magnitude happens and what we can do about it.

Resources:

• Read 16 Steps to Securing Your Data (and Life)
• Find Naftali on Twitter: https://x.com/naftaliharris
• Check out Sentilink: https://www.sentilink.com/

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This episode from Web3 with a16z Crypto, is all about innovation on a global scale, exploring both ecosystem and individual talent levels. We examine what works and what doesn’t, how certain regions evolve into startup hubs and economic powerhouses, and what constitutes entrepreneurial talent. We also discuss the nature of ambition, the journey to finding one’s path, and broader mindsets for navigating risk, reward, and dynamism across various regions, with a particular focus on London and Europe.

Joining us is Matt Clifford, who played a pivotal role in the London entrepreneurial and tech ecosystem since 2011, is the Chair of Entrepreneur First and the UK’s Advanced Research and Invention Agency (ARIA). Before this episode was recorded, Matt served as the Prime Minister’s representative for the AI Safety Summit at Bletchley Park. Recently, he was appointed by the UK Secretary of Science to deliver an “AI Opportunities Action Plan” to the UK government.

This episode was recorded live from Andreessen Horowitz’s first international office in London. For more on our efforts and additional content, visit a16zcrypto.com/uk.

Resources:

Find Matthew on Twitter: https://x.com/matthewclifford

Find Sonal on Twitter: https://x.com/smc90

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Once criticized for lacking ambition, French founders are now aiming to create the world’s largest companies. With a thriving ecosystem attracting talent from across Europe and the US, France is becoming a major player on the global stage.

In this episode, we cover the unique advantages of building startups in France. Roxanne Varza, Director of Station F; Antoine Martin, co-founder of Amo and Zenly; and Brian Kim, a16z consumer partner, discuss the key factors driving this transformation, including infrastructure, community, and government support.

Discover how international talent, a supportive community, and robust governmental backing are propelling France’s startup scene. This episode is filled with insights into why France is now an exciting place to build a startup.

Resources:

Find Roxanne on Twitter: https://x.com/roxannevarza

Find Antoine on Twitter: https://x.com/an21m

Find Bryan on Twitter: https://x.com/kirbyman01

Learn more about Station F: https://stationf.co/

Learn more about Amo: https://get.amo.co/en

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Waymo's autonomous vehicles have driven over 20 million miles on public roads and billions more in simulation.

In this episode, a16z General Partner David George sits down with Dmitri Dolgov, CTO at Waymo, to discuss the development of self-driving technology. Dmitri provides technical insights into the evolution of hardware and software, the impact of generative AI, and the safety standards that guide Waymo's innovations.

This footage is from AI Revolution, an event that a16z recently hosted in San Francisco. Watch the full event here:  a16z.com/dmitri-dolgov-waymo-ai

Resources: 

Find Dmitri on Twitter: https://x.com/dmitri_dolgov

Find David George on Twitter: https://x.com/DavidGeorge83

Learn more about Waymo: https://waymo.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The Olympics features over 11,000 athletes competing in 32 sports, attracting an audience of more than 10 million.

In this episode, Charlie Ebersol, co-founder of the Alliance of American Football and Infinite Athlete, explores how new innovations like AI and bespoke broadcasting technologies are shaping the future of sports.

Charlie also reflects on the storytelling legacy of his father, Dick Ebersol, a legendary sports producer who transformed how we experience the Olympics. We discuss the importance of making sports more accessible and engaging through technology that enhances, rather than distracts from, the human stories at the heart of the games.

Whether you're a tech enthusiast or a sports fan, this episode offers a unique look at the convergence of these two worlds.

Resources: 

Find Charlie on Twitter: https://x.com/CharlieEbersol

Learn more more about Infinite Athlete: https://infiniteathlete.ai/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

On June 27th, the a16z team headed to New York City for the first-ever AI Artist Retreat at their office. This event brought together the builders behind some of the most popular AI creative tools, along with 16 artists, filmmakers, and designers who are exploring the capabilities of AI in their work.

In this episode, we hear from the innovators pushing the boundaries of AI creativity. Joined by Anish Acharya, General Partner, and Justine Moore, Partner on the Consumer team, we feature insights from:

• Ammaar Reshi - Head of Design, ElevenLabs
• Justin Maier - Cofounder & CEO, Civitai
• Maxfield Hulker - Cofounder & COO, Civitai
• Diego Rodriguez - Cofounder & CTO, Krea
• Victor Perez - Cofounder & CEO, Krea
• Mohammad Norouzi - Cofounder & CEO, Ideogram
• Hang Chu - Cofounder & CEO, Viggle
• Conor Durkan - Cofounder, Udio

These leaders highlight the surprising commonalities between founders and artists, and the interdisciplinary nature of their work. The episode covers the origin stories behind these innovative tools, their viral moments, and their future visions. You'll also hear about the exciting potential for AI in various creative modalities, including image, video, music, 3D, and speech.

Keep an eye out for more in our series highlighting the founders building groundbreaking foundation models and AI applications for video, audio, photography, animation, and more.

Learn more and see videos on artists leveraging AI at: 

a16z.com/aiart

Find Ammaar on Twitter: https://x.com/ammaar

Learn more about ElevenLabs: https://elevenlabs.io

Find Justin on Twitter: https://x.com/justmaier

Find Max on LinkedIn: https://www.linkedin.com/in/maxfield-hulker-5222aa230/
Learn more about Civitai: https://civitai.com

Find Diego on Twitter: https://x.com/asciidiego?lang=en

Find Victor on Twitter: https://x.com/viccpoes

Learn more about Krea: https://www.krea.ai/home

Find Mohammed on Twitter: https://x.com/mo_norouzi

Learn more about Ideogram: https://ideogram.ai/t/explore

Find Conor on Twitter: https://x.com/conormdurkan

Learn more about Udio: https://www.udio.com/home

Find Hang on Twitter: https://x.com/chuhang1122

Learn more about Viggle: https://viggle.ai/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Gaming is not just entertainment—it's a revolution reshaping our culture, technology, and economy. 

a16z’s Jonathan Lai and Andrew Chen dive into the current gaming renaissance and its future impact. Joining them are Michael Chow, CEO and Steven Snow, CPO of The Believer Company, and Eros Resmini, Founder and Managing Partner of The Mini Fund.

They explore the intersection of tech, art, psychology, and design in gaming, discussing how startups can navigate intense competition, distribution challenges, and high production costs. With insights from these industry leaders, this episode covers the transformative potential of AI, the importance of player feedback, and strategies to stand out in a crowded market.

Recorded during Speedrun, a16z’s extensive games accelerator, this episode offers a glimpse into the strategies and innovations driving the gaming industry forward.

Resources: 

Find Steven on Twitter: https://twitter.com/StevenSnow

Find Michael on LinkedIn: https://www.linkedin.com/in/believer-paladin/

Find Eros on Twitter: https://twitter.com/erosresmini

Find Jonathan on Twitter: https://twitter.com/Tocelot

Find Andrew on Twitter: https://twitter.com/andrewchen

Learn more about Speedrun: https://a16z.com/games/speedrun/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Former gymnast and current investor Aly Raisman joins general partner Julie Yoo and investment partner Daisy Wolf of a16z Bio + Health.

In this episode, Aly Raisman shares her quest for healthier living—physically, mentally, and financially—on her journey from gymnast to a business investor. Having transitioned from an intensely structured routine, Aly emphasizes the need for more open conversations about mental health and financial literacy. She speaks passionately about the gap in women’s health solutions and hopes to inspire entrepreneurs to create impactful businesses. Aly’s experiences as a patient, survivor, and global figure adds a unique dimension to her perspective as an investor. This candid conversation with Aly and Julie Yoo sheds light on Aly’s passion for more education within the investment space, offering invaluable insights for entrepreneurs, particularly in biotech and healthcare.

Resources: 

Find Aly on Twitter: https://x.com/aly_raisman

Find Julie on Twitter: https://x.com/julesyoo

Find Daisy on Twitter: https://x.com/daisydwolf

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Less than two years since the breakthrough of text-based AI, we now see incredible developments in multimodal AI models and their impact on millions of users.

As part of New York Tech Week, we brought together a live audience and three leaders from standout companies delivering AI-driven products to millions. Gaurav Misra, Cofounder and CEO of Captions, Carles Reina, Chief Revenue Officer of ElevenLabs, and Laura Burkhauser, VP of Product at Descript discuss the challenges and opportunities of designing AI-driven products, solving real customer problems, and effective marketing.

From the critical need for preventing AI misuse to ensuring international accessibility, they cover essential insights for the future of AI technology.

Resources: 

Find Laura on Twitter: https://x.com/burkenstocks

Find Carles on Twitter :https://twitter.com/carles_reina

Find Gaurav of Twitter: https://twitter.com/gmharhar

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

"The Ben & Marc Show," featuring a16z co-founders Marc Andreessen and Ben Horowitz. 

In this special episode, Marc and Ben dive deep into the REAL story behind the creation of Netscape—a web browser co-created by Marc that revolutionized the internet and changed the world. As Ben notes at the top, until today, this story has never been fully told either in its entirety or accurately. 

In this one-on-one conversation, Marc and Ben discuss Marc's early life and how it shaped his journey into technology, the pivotal moments at the University of Illinois that led to the development of Mosaic (a renegade browser that Marc developed as an undergrad), and the fierce competition and legal battles that ensued as Netscape rose to prominence. 

Ben and Marc also reflect on the broader implications of Netscape's success, the importance of an open internet, and the lessons learned that still resonate in today's tech landscape (especially with AI). That and much more. Enjoy!

Watch the FULL Episode on YouTune: https://youtu.be/8aTjA_bGZO4

Resources: 

Marc on X: https://twitter.com/pmarca 

Marc’s Substack: https://pmarca.substack.com/ 

Ben on X: https://twitter.com/bhorowitz 

Book mentioned on this episode: 

- “Expert Political Judgment” by Philip E. Tetlock https://bit.ly/45KzP6M 

TV Series mentioned on this episode: 

- “The Mandalorian” (Disney+) https://bit.ly/3W0Zyoq

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

We know that technology has changed art, and that artists have evolved with every new technology — it’s a tale as old as humanity, moving from cave paintings to computers. Underlying these movements are endless debates around inventing versus remixing; between commercialism and art; between mainstream canon and fringe art; whether we’re living in an artistic monoculture now (the answer may surprise you); and much much more. 

So in this new episode featuring Berlin-based contemporary artist Simon Denny -- in conversation with a16z crypto editor in chief Sonal Chokshi -- we discuss all of the above debates. We also cover how artists experimented with the emergence of new technology platforms like the web browser, the iPhone, Instagram and social media; to how generative art found its “native” medium on blockchains, why NFTs; and other art movements. 

Denny also thinks of entrepreneurial ideas -- from Peter Thiel's to Chris Dixon's Read Write Own -- as an "aesthetic"; and thinks of technology artifacts (like NSA sketches!) as art -- reflecting all of these in his works across various mediums and contexts. How has technology changed art, and more importantly, how have artists changed with technology? How does art change our place in the world, or span beyond space? It's about optimism, and seeing things anew... all this and more in this episode.

Resources: 

Find Denny on Twitter: https://x.com/dennnnnnnnny

Find Sonal on Twitter: https://x.com/smc90

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Is it time to hand over cybersecurity to machines amidst the exponential rise in cyber threats and breaches?

We trace the evolution of cybersecurity from minimal measures in 1995 to today's overwhelmed DevSecOps. Travis McPeak, CEO and Co-founder of Resourcely, kicks off our discussion by discussing the historical shifts in the industry. Kevin Tian, CEO and Founder of Doppel, highlights the rise of AI-driven threats and deepfake campaigns. Feross Aboukhadijeh, CEO and Founder of Socket, provides insights into sophisticated attacks like the XZ Utils incident. Andrej Safundzic, CEO and Founder of Lumos, discusses the future of autonomous security systems and their impact on startups.

Recorded at a16z's Campfire Sessions, these top security experts share the real challenges they face and emphasize the need for a new approach. 

Resources: 

Find Travis McPeak on Twitter: https://x.com/travismcpeak

Find Kevin Tian on Twitter: https://twitter.com/kevintian00

Find Feross Aboukhadijeh on Twitter: https://x.com/feross

Find Andrej Safundzic on Twitter: https://x.com/andrejsafundzic

Stay Updated: 

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Brooke Boyarsky Pratt, founder and CEO of knownwell, joins Vineeta Agarwala, general partner at a16z Bio + Health.

Together, they talk about the value of obesity medicine practitioners, patient-centric medical homes, and how Brooke believes the metabolic health space will evolve over time.

This is the second episode in Raising Health’s series on the science and supply of GLP-1s. Listen to last week's episode to hear from Carolyn Jasik, Chief Medical Officer at Omada Health, on GLP-1s from a clinical perspective.

Listen to more from Raising Health’s series on GLP-1s:

The science of satiety: https://raisinghealth.simplecast.com/episodes/the-science-and-supply-of-glp-1s-with-carolyn-jasik

Payers, providers and pricing: https://raisinghealth.simplecast.com/episodes/the-science-and-supply-of-glp-1s-with-chronis-manolis

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this latest episode on the State of AI, Ben and Marc discuss how small AI startups can compete with Big Tech’s massive compute and data scale advantages, reveal why data is overrated as a sellable asset, and unpack all the ways the AI boom compares to the internet boom.

Subscribe to the Ben & Marc podcast: https://link.chtbl.com/benandmarc

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Over the past decade, usage-based pricing has soared in popularity. Why? Because it aligns cost with value, letting customers pay only for what they use. But, that flexibility is not without issues - especially when it comes to predicting revenue. Fortunately, with the right process and infrastructure, your usage-based revenue can become more predictable than the traditional seat-based SaaS model. 

In this episode from the a16z Growth team, Fivetran’s VP of Strategy and Operations Travis Ferber and Alchemy’s Head of Sales Dan Burrill join a16z Growth’s Revenue Operations Partner Mark Regan. Together, they discuss the art of generating reliable usage-based revenue. They share tips for avoiding common pitfalls when implementing this pricing model - including how to nail sales forecasting, adopting the best tools to track usage, and deal with the initial lack of customer data. 

Resources: 

Learn more about pricing, packaging, and monetization strategies: a16z.com/pricing-packaging

Find Dan on Twitter: https://twitter.com/BurrillDaniel

Find Travis on LinkedIn: https://www.linkedin.com/in/travisferber

Find Mark on LinkedIn: https://www.linkedin.com/in/mregan178

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

On May 21, the California Senate passed bill 1047.

This bill – which sets out to regulate AI at the model level – wasn’t garnering much attention, until it slid through an overwhelming bipartisan vote of 32 to 1 and is now queued for an assembly vote in August that would cement it into law. In this episode, a16z General Partner Anjney Midha and Venture Editor Derrick Harris breakdown everything the tech community needs to know about SB-1047.

This bill really is the tip of the iceberg, with over 600 new pieces of AI legislation swirling in the United States. So if you care about one of the most important technologies of our generation and America’s ability to continue leading the charge here, we encourage you to read the bill and spread the word.

Read the bill: https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202320240SB1047

Consumer AI is moving fast, so who's leading the charge? 

a16z Consumer Partners Olivia Moore and Bryan Kim discuss our GenAI 100 list and what it takes for an AI model to stand out and dominate the market.

They discuss how these cutting-edge apps are connecting with their users and debate whether traditional strategies like paid acquisition and network effects are still effective. We're going beyond rankings to explore pivotal benchmarks like D7 retention and introduce metrics that define today's AI market.

Note: This episode was recorded prior to OpenAI's Spring update. Catch our latest insights in the previous episode to stay ahead!

Resources:

Link to the Gen AI 100: https://a16z.com/100-gen-ai-apps

Find Bryan on Twitter: https://twitter.com/kirbyman01

Find Olivia on Twitter: https://x.com/omooretweets

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

a16z General Partner David Haber talks with Marty Chavez, vice chairman and partner at Sixth Street Partners, about the foundational role he’s had in merging technology and finance throughout his career, and the magical promises and regulatory pitfalls of AI.

This episode is taken from “In the Vault”, a new audio podcast series by the a16z Fintech team. Each episode features the most influential figures in financial services to explore key trends impacting the industry and the pressing innovations that will shape our future. 

Resources: 
Listen to more of In the Vault: https://a16z.com/podcasts/a16z-live

Find Marty on X: https://twitter.com/rmartinchavez

Find David on X: https://twitter.com/dhaber

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This was a big week in the world of AI, with both OpenAI and Google dropping significant updates. So big that we decided to break things down in a new format with our Consumer partners Bryan Kim and Justine Moore. We discuss the multi-modal companions that have found their voice, but also why not all audio is the same, and why several nuances like speed and personality really matter.

Resources:

OpenAI’s Spring announcement: https://openai.com/index/hello-gpt-4o/

Google I/O announcements: https://blog.google/technology/ai/google-io-2024-100-announcements/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Make sure to check out our new AI + a16z feed: https://link.chtbl.com/aiplusa16z
 

a16z General Partner Anjney Midha joins the podcast to discuss what's happening with hardware for artificial intelligence. Nvidia might have cornered the market on training workloads for now, but he believes there's a big opportunity at the inference layer — especially for wearable or similar devices that can become a natural part of our everyday interactions. 

Here's one small passage that speaks to his larger thesis on where we're heading:

"I think why we're seeing so many developers flock to Ollama is because there is a lot of demand from consumers to interact with language models in private ways. And that means that they're going to have to figure out how to get the models to run locally without ever leaving without ever the user's context, and data leaving the user's device. And that's going to result, I think, in a renaissance of new kinds of chips that are capable of handling massive workloads of inference on device.

"We are yet to see those unlocked, but the good news is that open source models are phenomenal at unlocking efficiency.  The open source language model ecosystem is just so ravenous."

More from Anjney:

The Quest for AGI: Q*, Self-Play, and Synthetic Data

Making the Most of Open Source AI

Safety in Numbers: Keeping AI Open

Investing in Luma AI

Follow everyone on X:

Anjney Midha

Derrick Harris

Check out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2009 Discord cofounder and CEO, Jason Citron, started building tools and infrastructure for games. Fast forward to today and the platform has over 200 million monthly active users. 

In this episode, Jason, alongside a16z General Partner Anjney Midha—who merged his company Ubiquity6 with Discord in 2021—shares insights on the nuances of community-driven product development, the shift from gamer to developer, and Discord’s longstanding commitment to platform extensibility. 

Now, with Discord's recent release of embeddable apps, what can we expect now that it's easier than ever for developers to build? 

Resources: 

Find Jason on Twitter: https://twitter.com/jasoncitron

Find Anjney on Twitter: https://twitter.com/AnjneyMidha

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Human nature fears the unknown, and with the rapid progress of AI, concerns naturally arise. Uncanny robocalls, data breaches, and misinformation floods are among the worries. But what about security in the era of large language models?

In this episode, we hear from security leaders at OpenAI, Anthropic, and Google DeepMind. Matt Knight, Head of Security at OpenAI, Jason Clinton, CISO at Anthropic, and Vijay Bolina, CISO at Google DeepMind, are joined by Joel de la Garza, operating partner at a16z and former chief security officer at Box and Citigroup.

Together, they explore how large language models impact security, including changes in offense and defense strategies, misuse by nation-state actors, prompt engineering, and more. In this changing environment, how do LLMs transform security dynamics? Let's uncover the answers.

Resources:

Find Joel on LinkedIn: https://www.linkedin.com/in/3448827723723234/

Find Vijay Bolina on Twitter: https://twitter.com/vijaybolina

Find Jason Clinton on Twitter: https://twitter.com/JasonDClinton

Find Matt Knight  on Twitter: https://twitter.com/embeddedsec

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In recent years, the AI landscape has seen huge advancements, from the release of Dall-E 2 in April 2022 to the emergence of AI music and video models in early 2024.

While creative tools often steal the spotlight, AlphaFold 2 marked a groundbreaking AI breakthrough in biology in 2021. Since its release, this pioneering tool for predicting protein structures has been utilized by over 1.7 million scientists worldwide, influencing fields ranging from genomics to computational chemistry.

In this episode, DeepMind's VP of Research for Science, Pushmeet Kohli, and a16z General Partner Vijay Pande discuss the transformative potential of AI in scientific exploration. Can AI lead to fundamentally new discoveries in science? Let's find out.

Resources: 

Find Pushmeet on Twitter: https://twitter.com/pushmeet

Find Vijay on Twitter: https://twitter.com/vijaypande

Learn more about Google DeepMind: https://deepmind.google

Read DeepMind’s AlphaFold whitepaper: https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold

Read DeepMind’s AlphaGeometry: https://deepmind.google/discover/blog/alphageometry-an-olympiad-level-ai-system-for-geometry

Read DeepMind’s research on new materials: https://deepmind.google/discover/blog/millions-of-new-materials-discovered-with-deep-learning/

Read DeepMind’s paper on FunSearch, focused on new discoveries in mathematics: https://deepmind.google/discover/blog/funsearch-making-new-discoveries-in-mathematical-sciences-using-large-language-models

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Over 3,700 companies applied to a16z’s SPEEDRUN. In this episode, we meet the founders pushing the boundaries of what games can be.

From the fusion of traditional gaming elements with modern tech-twists, a16z General Partner Andrew Chen and Partner Josh Lu discuss the challenges and wins of creating games that are not only fun but also integrate seamlessly into the digital age, from AI-twins to games that “move at the speed of culture”. 

Whether you’re a developer, an enthusiast, or just curious about the future of interactive entertainment, this episode provides a glimpse into how today's creators use creativity and technology to captivate.

If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3.

Resources: 

Submit your SPEEDRUN 3.0 application: https://a16z.com/speedrun-la-2024

Find Andrew on Twitter: https://twitter.com/andrewchen

Find Josh on Twitter: https://twitter.com/JoshLu

Learn more about Avi and Magic Circle: https://twitter.com/aviromanoff

Learn more about Lil Snack: https://www.lilsnack.co

Learn more about Neon Wild: https://www.neonwild.com

Learn more about Open Souls: https://www.opensouls.studio

Learn more about Altera: https://altera.al

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Senator Todd Young (R-IN) speaks with a16z General Partner Martin Casado about the importance of open innovation and American leadership in AI, and why we need to support AI research at all levels — from the classroom to the war room.

In this episode, we distinguish science fiction from science reality in the ever-evolving AI landscape.

Resources:

Find Senator Todd Young on Twitter: https://twitter.com/toddyoungin

Find Martin Casado on Twitter: https://twitter.com/martin_casado

Watch the American Dynamism stage talks on YouTube: https://bit.ly/3IqWn1W

To learn more about the American Dynamism Summit, visit our website: a16z.com/ad-summit

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The gaming industry stands as a pioneer of cutting-edge technologies, ushering in innovations like GPUs, virtual and augmented reality, physics engines, and immersive multiplayer experiences. 

In this episode, a16z cofounder Marc Andreessen and Andrew Chen, General Partner at a16z Games, dig into why a16z was compelled to establish a dedicated games fund. They explore the origins of tech pessimism, effective engagement with government in tech, its significance for the gaming community, the ongoing AI revolution, and even what Marc himself would build today if he didn't have his hands full. 

Recorded as part of a16z's extensive games fund accelerator, SPEEDRUN, this session offers valuable insights for founders and innovators at the intersection of games and technology. 

If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3.

Resources: 

Find Marc on Twitter: https://twitter.com/pmarca

Find Andrew on Twitter: https://twitter.com/andrewchen

Submit your SPEEDRUN 3.0 application: https://a16z.com/speedrun-la-2024

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From air-defining radar and electronic systems that helped the Allies win World War II, the origins of Silicon Valley are deeply rooted in government and defense.

In today's episode, we get the chance to revisit that relationship with the United States Deputy Secretary of Defense, Kathleen Hicks.

Deputy Secretary Hicks has spent decades of her career focused on defense policy and in her keynote address from a16z's second annual American Dynamism Summit in Washington, D.C., you'll get an inside look into the priorities of the DoD and how it views its past, present, and future.

In the second half of the episode, you’ll hear highlights from Deputy Secretary Hicks' fireside chat with Wall Street Journal’s National Security Editor, Sharon Weinberger, where they dive into the numerous issues facing our country today, from Ukraine to the use of AI on the battlefield.

Resources: 

Find Deputy Secretary Hicks on Twitter: https://twitter.com/depsecdef

Find Sharon on Twitter: https://twitter.com/weinbergersa

To learn more about the American Dynamism Summit: www.a16z.com/ad-summit

Visit the full playlist of American Dynamism Summit videos on YouTube: https://bit.ly/3IqWn1W

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

“If America is going to be America in the next one hundred years, we have to get this right.” - Ben Horowitz

This week on “The Ben & Marc Show”, a16z co-founders Ben Horowitz and Marc Andreessen take on one of the most hot button issues facing technology today: tech regulation and policy.

In this one-on-one conversation, Ben and Marc delve into why the political interests of “Big Tech” conflict with a positive technological future, the necessity of decentralized AI, and how the future of American innovation is at its most critical point. They also answer YOUR questions from X (formerly Twitter). That and much more. Enjoy!

Resources:

Watch full episode: https://youtu.be/dX7d6bRJI9k

Marc on X: https://twitter.com/pmarca

Marc’s Substack: https://pmarca.substack.com

Ben on X: https://twitter.com/bhorowitz

Ben’s Article: “Politics and the Future” bit.ly/3PGKrgw

Stay Updated: 

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From judging inventions on “Shark Tank” to reshaping the image of NBA ownership, Mark Cuban is known for many things. In this chat with a16z General Partner David Ulevitch, he discusses the importance of entrepreneurship for maintaining America’s status as the most innovative place on the planet. This includes making big bets, like he’s doing with Cost Plus Drugs, his latest venture that seeks to upend the prescription drug markets.

Resources: 

Find Mark on Twitter: https://twitter.com/mcuban

Find David Ulevitch on Twitter: https://twitter.com/davidu

Learn more about the American Dynamism Summit: www.a16z.com/ad-summit

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

At the a16z LP Summit, we brought hundreds of our limited partners and portfolio founders together in Las Vegas.

The event was truly overflowing with stories of how founders are challenging the status quo and harnessing technology to make the world a better place. Amidst these stories, it became clear that in the realms of public safety and healthcare, the stakes couldn't be higher—these sectors not only hold lives in balance but also stand as fertile ground for technological breakthroughs.

In this episode, a16z General Partner Vijay Pande chats with Ed and Todd Park, the visionary siblings behind Devoted Health. Their mission? To overhaul a healthcare system they describe as critically essential yet deeply flawed. The Park brothers delve into the genesis of their ambition to construct a healthcare system from scratch, underscoring the sector's urgent need for technological innovation and the game-changing role of AI.

Kicking off with an American dream story, this episode is a must-listen for anyone interested in how technology can reshape healthcare for the better.

Resources: 

Find Vijay on Twitter: https://twitter.com/vijaypande

Find Ed on Twitter: https://twitter.com/edparkdevoted

Find Todd on LinkedIn: https://www.linkedin.com/in/todd-park-3232573

Learn more about Devoted Health: https://www.devoted.com

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Generative AI has initiated a transformative shift, reshaping our world in unprecedented ways. In a16z's AI Revolution series, we engage some of the most impactful builders in the field of AI discussing and debating where we are, where we’re going, and the big open questions in AI.

In this episode, General Partner David George chats with Adam D'Angelo, the CEO and founder of Quora, wade into this fast-moving AI landscape, and specifically touch on how building infrastructure for creators can democratize AI. 

Adam, who is now building AI aggregator Poe and is on the board of OpenAI, has long been paying attention to this AI wave. He recounts this evolving fascination, and together Adam and David explore the dynamic synergy between humans and AI, highlighting the critical role of experimentation for founders in the AI realm.

As a reminder, this conversation comes from our AI Revolution series, which you can dive into more deeply at a16z.com/ai. 

Resources:

Watch the the full interview: www.a16z.com/AIRevolution

Find Adam on Twitter: https://twitter.com/adamdangelo

Find David George on Twitter: https://twitter.com/DavidGeorge83

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Nuclear energy accounts for 20% of the electricity in the United States, but remarkably, 2023 marked the commissioning of the U.S.'s first new nuclear reactor in over three decades. The past few years have been a story of changing public opinion, but equally, innovative startups crafting groundbreaking reactor designs and an ambitious announcement by the U.S. government to triple nuclear power production by 2050.

In this episode recorded at a16z’s American Dynamism Summit in Washington DC, a16z podcast host Steph Smith is joined by a16z General Partner David Ulevich, Doug Bernauer – CEO of microreactor company Radiant – and Dr. Kathryn Huff, Assistant Secretary of the Office of Nuclear Energy.

From energizing the country's data centers to propelling the electric vehicles on our roads or powering the factories crafting tomorrow's innovations, they discuss why expanding our nuclear capacity is a national imperative. 

Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington DC.

Topics Covered: 

00:00 - The Promise of Advanced Nuclear Reactors

03:43 - Nuclear Energy's Current Landscape

07:00 - Vulnerabilities in Fuel Delivery

10:30 - Nuclear Energy's Timeline

12:11 - Portable Microreactors and Mass Production 

15:06 - Nuclear Energy's Role in America

21: 24 - Government's Role in Nuclear Energy

26:08 - Challenges of Portable Micro Reactors

 30:03- The Evolution of Nuclear Reactors

32:11 - Nuclear’s Public Perception and Safety

39:21 - The Global Need for Nuclear Power

Resources:

Learn more about American Dynamism Summit 2024: www.a16z.com/adsummit

Find Dr. Kathryn Huff on Twitter: https://twitter.com/katyhuff

Find Doug Bernauer and Radiant on Twitter: https://twitter.com/radiantnuclear

Find David Ulevitch on Twitter: https://twitter.com/davidu

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Artificial intelligence has taken the world by storm. But despite the hype around personalized avatars or podcast language translation, artificial intelligence is not only impacting the creative spheres; in fact it’s hard to find an industry that isn’t being touched by this technology – and defense of our country is far from excluded.

In this episode, originally recorded in the heart of Washington DC this January during a16z’s American Dynamism Summit, a16z General Partner Martin Casado and a16z enterprise editor, Derrick Harris are joined by the first-ever CTO of the CIA, Nand Mulchandani.

In this wide-ranging conversation, they discuss the evolving relationship between analysts and AI, how governments can keep up with this exponential technology, and finally, how it’s impacting both offense and defense.  

This episode is essential listening for anyone interested in the intersection of technology, national security, and policy-making in the age of artificial intelligence. Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington DC.

Topics Covered:

00:00 - Intelligence in the Age of AI

02:28 - Rethinking Jobs and AI's Asymmetric Power

05:00 - The History of AI in the Intelligence Community

07:00 - Operational Utilization of AI

10:40 - Analytic Capabilities and Uncertainty

12:56 - AI's 'Hallucination' Concerns

16:37 - Analyst Skill Sets and AI Tools

26:29 - Supply Chain and Open Source

31:35 - Public-Private Partnerships

41:33 - Government as a Customer and Partner in Tech

42:43 - Policy, Technology, and Regulation

Resources

Learn more about AD Summit 2024: www.a16z.com/adsummit

Watch all of the stage talks at AD Summit 2024: https://www.youtube.com/playlist?list=PLM4u6XbiXf5pAKmk1AeZ9964KGScf4lHM

Read the CIA’s announcement around the new CTO role: https://www.cia.gov/stories/story/cia-names-first-chief-technology-officer/

Find Nand Mulchandani on Twitter: https://twitter.com/nandmulchandani

Find Martin on Twitter: https://twitter.com/martin_casado

Find Derrick on Twitter: https://twitter.com/derrickharris

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The last few decades have been a period of transition for defense. An increasing number of startups have begun to rival large defense primes, the industry has gradually become a calculus of both hardware and software, and exponential technologies have forced the DoD to rethink how it has  traditionally done business.

These changing conditions were some of the inputs to resulting in the DIU – Defense Innovation Unit – starting in 2015 within the Department of Defense, focused on accelerating the adoption of technology.

In this episode recorded at a16z’s American Dynamism Summit in January, a16z General Partner Katherine Boyle is joined by the Director of the DIU, Doug Beck, plus two critical founders ushering in this new era of defense: Brian Schimpf, cofounder and CEO of Anduril and Brandon Tseng, cofounder of Shield AI.

So what does the next wave of defense innovation really look like? Let’s find out.

00:00 - The Future of Defense Innovation 

03:30 - The Defense Innovation Unit (DIU)

05:45 - Adoption of Startup tech by the DoD

07:42 - Acquisition, Budgeting, and Contracting

13:17 - Traditional Primes vs Startups

14:25 - Cost-Plus Fixed Fee Contracts

20:11 - The Replicator Program

22:26 - The New Threat Environment

27:11 - Scale and Readiness for Modern Warfare

32:15 - Procurement Reform and Feasibility

39:30 - Success Metrics for Defense

Resources:

Learn more about AD Summit 2024: www.a16z.com/adsummit

Watch Brian’s stage talk at AD Summit 2024: https://a16z.com/securing-americas-future-how-technology-companies-and-washington-are-building-a-safer-world/

Watch all of the stage talks at AD Summit 2024: https://www.youtube.com/playlist?list=PLM4u6XbiXf5pAKmk1AeZ9964KGScf4lHM

Find Katherine on Twitter: https://twitter.com/KTmBoyle

Find Brandon and Shield AI on Twitter: https://twitter.com/shieldaitech

Find Brian on Twitter: https://twitter.com/schimpfbrian

Find Doug and the DIU on Twitter: https://twitter.com/diu_x

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

American Dynamism. A term coined by a16z General Partner, Katherine Boyle, two years ago, when she and David Ulevitch founded the firm's American Dynamism investing practice.

Beyond a sector or movement, American Dynamism embodies innovation, community, and a unique philosophy touching every facet of American life.

In this episode, we hear from 10 voices, including policymakers, founders, and funders, as they share what American Dynamism means to them. They discuss the critical technologies shaping the future and the challenges on the path to the next decade of dynamism. 

Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington, D.C.

Resources: 

Find Dr. Kathryn Huff on Twitter: https://twitter.com/katyhuff

Find Nand Mulchandani on Twitter: https://twitter.com/nandmulchandani

Find Doug Beck and the DIU on Twitter: https://twitter.com/diu_x

Find Mitch Lee on Twitter: https://twitter.com/dontmitch

Find Ian Cinnamon on Twitter: https://twitter.com/IanCinnamon

Find Doug Bernauer and Radiant on Twitter: https://twitter.com/radiantnuclear

Find Chris Bennett on Twitter: https://twitter.com/8ennett

Find Mike Slagh on Twitter: https://twitter.com/MikeSlagh

Find Rahul Sidhu on Twitter: https://twitter.com/rahoolsidoo

Find Wyatt Smith on Twitter: https://twitter.com/wyatt_h_smith

Learn more about American Dynamism: https://a16z.com/american-dynamism

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

You might recognize the name Mark Pincus but we almost guarantee you recognize the game Farmville. 

Mark Pincus is the founder and longtime CEO of Zynga, known for its massive global franchise of games, including those household names like Farmville and Words with Friends. Zynga was also at the forefront of the transition to mobile and the use of large platforms like Facebook for distribution.

In this episode Mark joins Josh Lu from the a16z Games team for a fireside chat. They discuss navigating major tech waves and recognizing "true signal" opportunities, and explore a wide range of topics, from the strategic insights that propelled Zynga to success, the future of the Metaverse, and the philosophy behind minimum viable products. 

This conversation offers invaluable insights for both gaming industry insiders and enthusiasts looking to understand the dynamics of tech innovation and entrepreneurship.

Topics Covered:

00:00 - How Zynga Spotted the Mobile Wave

02:47 - Challenges of Starting Zynga

05:24 - Zynga's Early Workforce and Learning HTML

07:40 - Preparing for Tech Waves

11:29 - The Importance of Being Too Early

15:42 - The attribute of great founders

18:33 - Hiring Philosophy 

22:02 - ‘Everyone is  a CEO’

24:20 - Fast Iteration and Learning from Failures

31:06 - Personal Gaming Preferences

32:52 - Advice on Reevaluating Projects and True Signal

35:50 - AI's Role in Consumer Adoption and Gaming

40:17 - Community as a Core Element

43:31 - UGC Gaming Space and Future Computing Paradigms

Resources: 

Find Mark on Twitter: https://twitter.com/markpinc

Find Josh on Twitter: https://twitter.com/joshlu

Learn more about SPEEDRUN 3.0: https://a16z.com/speedrun3

Learn more about SPEEDRUN: ttps://a16z.com/speedrun-your-gaming-startup

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In early 2024, the notion of high fidelity, believable AI-generated video seemed a distant future to many. Yet, a mere few weeks into the year, OpenAI unveiled Sora, its new state of the art text-to-video model producing videos of up to 60 seconds. The output shattered expectations – even for other builders and researchers within generative AI – sparking widespread speculation and awe.

How does Sora achieve such realism? And are explicit 3D modeling techniques or game engines at play?

In this episode of the a16z Podcast, a16z General Partner Anjney Midha connects with Stefano Ermon, Professor of Computer Science at Stanford and key figure at the lab behind the diffusion models now used in Sora, ChatGPT, and Midjourney. Together, they delve into the challenges of video generation, the cutting-edge mechanics of Sora, and what this all could mean for the road ahead.

Resources: 

Find Stefano on Twitter: https://twitter.com/stefanoermon

Find Anjney on Twitter: https://twitter.com/anjneymidha

Learn more about Stefano’s Deep Generative Models course: :

https://deepgenerativemodels.github.io

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The electric grid needs an update. 

In this explainer, a16z Partner Ryan McEntush discusses the escalating complexity of the grid, unveils its vulnerabilities, and traces the evolutionary path that has led us to this point. From the surging demands of AI to outdated infrastructure, we delve into the potential roles of cutting-edge technologies such as solar batteries, natural gas, and nuclear power in shaping the grid's future.

Timestamps:

(00:00) - Introduction

(02:28) - The Need for Grid Modernization

(04:43) - Understanding the Grid's Operation and Challenges

(06:47) - The Complexity of Grid Management

(08:31) - Increasing Outages and Volatility

(11:49) - The Role of New Technologies

(17:53) - The Potential and Limitations of Renewable Energy Sources

(19:08) - Energy Storage Solutions

(24:57) - The Future of Natural Gas and Nuclear Power

(29:46) - The Impact of Policy on the Grid

(31:47) - The Concept of a Smart Grid

(34:04) - Decentralization of the Grid

(36:57) - The Role of the Free Market in Grid Reliability

Resources: 

Find Ryan on Twitter: https://twitter.com/rmcentush

Read Ryan’s latest articles: https://a16z.com/author/ryan-mcentush

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

"The Ben & Marc Show" features a16z's co-founders Ben Horowitz & Marc Andreessen. In this episode, Marc and Ben continue their in-depth exploration of the current education system. While Part I of their discussion unpacked the crisis facing higher education, Part II presents solutions to overhaul the modern university.

In this one-on-one conversation, Ben and Marc delve into actions that existing institutions can take to improve their current and future situations. This includes exploring new methods for talent recruitment, providing a more individualized education experience for students, and reducing administrative bloat. They also apply an entrepreneurial lens to each university function, revealing startup opportunities poised to emerge – including the building of brand new institutions, nonprofits, and research entities. Enjoy!

Resources:
*Watch Part I: https://youtu.be/7J2_G4oHRQ0
*Watch Part II: https://youtu.be/EeIdalo2huI

Marc on X: https://twitter.com/pmarca
Marc’s Substack: https://pmarca.substack.com/
Ben on X: https://twitter.com/bhorowitz
“South Park” episode mentioned in this discussion: – Eps 1505 (stream on Max): https://bit.ly/3HrZQg0

Stay Updated:

Find us on X: https://twitter.com/a16z
Find us on LinkedIn: https://www.linkedin.com/company/a16z

with @cdixon @rhhackett

Welcome to the web3 with a16z crypto podcast. I'm Robert Hackett, an editor here at a16z crypto, and I'm here with Chris Dixon, founding partner of a16z crypto and author of the new book Read Write Own: Building the Next Era of the Internet.  I had the privilege of editing Chris throughout the book writing process, and I'm thrilled now to talk to you about what went on behind the scenes, the big themes of the book, the challenges, and also about the crypto industry at large as well as what we can expect from it in the future.

Learn more at https://readwriteown.com/.

Resources for references in this episode:

• Black Swan by Nassim Nicholas Taleb
• The Tipping Point by Malcolm Gladwell
• Spider-Man: Across the Spider-verse
• "'It's a canon event' TikTok trend, explained"
• Chris Dixon's blog at cdixon.org
  • "Come for the tool, stay for the network"
  • "The next big thing starts out looking like a toy"
  • "Can't be evil"
• The Cold Start Problem by Andrew Chen
  • On Andrew Chen's writing habits
• On investing in Coinbase in 2013
• Guidance from the U.S. Securities & Exchange Commission in 2019: "Framework for 'Investment Contract' Analysis of Digital Assets"
• On blockchains as "a programmable computer that lives in the sky" via a16z crypto head of research Tim Roughgarden
• Gödel Escher Bach by Douglas Hofstader
• "How Aristotle Created the Computer" by Chris Dixon for The Atlantic
• "A Symbolic Analysis of Relay and Switching Circuits" by Claude Shannon
• Principia Mathematica by Bertrand Russell and Alfred North Whitehead
• An Investigation of the Laws of Thought by George Boole
• The End of Education by Neil Postman
• "Inside out vs. outside in: The adoption of new technologies" by Chris Dixon
• "The Inevitable Showdown Between Twitter and Twitter Apps" by Chris Dixon
• "Elon Musk says X is discouraging links in posts" by Sara Fischer
• "Make Ethereum Cypherpunk Again" by Vitalik Buterin
• "What Will Happen in 2024" by Fred Wilson
• "A Logical Calculus of the Ideas Immanent in Nervous Activity" by McCullough and Pitts
• Crossing the Chasm by Geoffrey A. Moore
• On "thesis, antithesis, and synthesis" and Hegel's Dialectics

As a reminder, none of the following should be taken as business, legal, tax, or investment advice; please see a16z.com/disclosures for more important information, including a link to a list of our investments.

In 2022 and 2023, US IPOs hit decade lows after the record high of 2021. Now, in 2024, will the IPO window reopen?

In this episode, we revisit a conversation with Jeff Jordan, former CEO of OpenTable, and J.D. Moriarty, the former Head Managing Director and Head of Equity Capital Markets at Bank of America Merrill Lynch.

Joined by Sonal Choksi, the pair takes you behind the scenes to unravel the complexities surrounding IPOs, including pricing, allocations, and the elusive "pop." They also discuss OpenTable’s IPO, which occurred immediately following the worst financial crisis since the Great Depression, and weigh in on the question: Can you time an IPO in an unpredictable year?

Resources:

Find Jeff on Twitter: https://twitter.com/jeff_jordan

Find J.D on LinkedIn: https://www.linkedin.com/in/jdmoriarty

Find Sonal on Twitter: https://twitter.com/smc90

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

(00:00) - The Future of Jobs

(03:15) - Job growth over the last 80 years

(05:06) - The shelf-life of jobs

(09:11) - Education trends

(12:25) - The importance of learning the foundations

(17:18) - Regional access to education

(20:19) - How companies are hiring and looking at strategic priorities

(22:58) - The economic mobility and economic stability of degrees 

(25:59) - Job and training trends at Grow with Google

(28:11) - Do companies train or hire for skills?

(29:23) - The future of the traditional degree

(31:10) - The employer and educator ecosystem 

(35:36) - How to approach upskilling 

In a world where technology is moving at an unprecedented pace, what will the jobs of the future look like?

Kai Roemmelt, CEO of the online learning platform Udacity, and Lisa Gevelber, a key figure at Google responsible for building the Grow with Google program, unpack the seismic changes reshaping the tech and education realms.

From disrupting hiring norms to redefining how we acquire degrees and engage globally, this episode poses the question: How can you skillfully navigate the challenges and seize the opportunities awaiting in this evolving landscape?

Resources: 

Find Kai on LinkedIn: https://www.linkedin.com/in/kai-roemmelt

Find Lisa on LinkedIn: https://www.linkedin.com/in/lisagevelber

Learn more about Udacity: https://www.udacity.com

Learn more about Grow with Google: https://grow.google

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Big news from a16z: Bio Eats World, our sibling show from a16z Bio+Health, is now Raising Health!

We’re excited to share Raising Health’s first episode here where Sean Duffy, cofounder and CEO of Omada Health, joins Vijay Pande, founding general partner of Bio + Health.

Sean and Vijay discuss the building and growth of Omada, from the early days to now. As the cofounder of one of the original digital health companies, Sean has unique insight into the growth of both the digital health field and the changing venture capital environment. They also talk about the future of AI, how Omada is leveraging AI, and the challenges that might arise with using a technology in a caregiving environment.

You can listen to more episodes of Raising Health here: https://link.chtbl.com/IqBoJ2By?sid=a16z11824

In this one-on-one conversation, Marc and Ben tackle the university system – what has certainly been a hot topic that’s been dominating the news over the past few months. As Marc states at the top of the episode, universities matter tremendously to our world, but they’re currently in a state of crisis.

Together, Ben and Marc take a “structural” look at higher education, delving deep into the twelve functions of the modern university.  They also unpack the numerous challenges that universities face today – student debt and the replication crisis, among them. 

They also discuss topics including DEI, student athlete admissions, accreditation, inflation, and much more. 

As colleges face an existential threat that could have long lasting repercussions, how can we find ways to improve these institutions, while being open to new entrepreneurial opportunities in education?

Check out the Ben and Marc show: https://link.chtbl.com/benandmarc

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Flock is a public safety technology platform that operates in over 4,000 cities across the United States, and solves about 2,200 crimes daily. That’s 10 percent of reported crimes nationwide.

Taken from a16z’s recent LP Summit, a16z General Partner David Ulevitch  joins forces with Flock Safety’s founder, Garrett Langley and Sheriff Kevin McMahill of the Las Vegas Metropolitan Police Department. Together, they cover the delicate balance between using technology to combat crime and respecting individual privacy, and explore the use of drones and facial recognition, building trust within communities, and the essence of objective policing.

Resources: 

Find Garret on Twitter: https://twitter.com/glangley

Find Sheriff McMahill on Twitter:  https://twitter.com/Sheriff_LVMPD

Find David on Twitter:https://twitter.com/davidu

Learn more about Flock Safety: https://www.flocksafety.com

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z 

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z 

Subscribe on your favorite podcast app: https://a16z.simplecast.com/ 

Follow our host: https://twitter.com/stephsmithio 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Nature’s blueprint – DNA – is an incredibly efficient machine. You cannot see it with the naked eye, yet it can last for hundreds, maybe even millions of years. Plus, the storage capacity of a single gram of DNA is over 200 million gigabytes! As the cost of DNA sequencing (reading) and synthesis (writing) comes down, scientists are looking to our very own biology for applications reaching as far as data storage. Learn more about this fascinating world with a16z General Partner Vijay Pande, as he says, this next wave of biological computing will “be the mother of many new exponentials to come.”

Resources: 

Save As: DNA Part 1: https://exo.substack.com/p/saving-our-story-in-dna-part-1

Save As: DNA Part 1: https://exo.substack.com/p/save-as-dna-part-2

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As we close off 2023, we wanted to revisit some of our favorite episodes from the last year. From AI hardware, to healthcare regulation, to disrupting the world’s largest asset class, to the electrification of nearly everything… there’s  something in here for all listeners.

Resources: 

AI Hardware, Explained:

https://a16z.simplecast.com/episodes/ai-hardware-explained

Chasing Silicon: The Race for GPUs: https://a16z.simplecast.com/episodes/chasing-silicon-the-race-for-gpus

The True Cost of Compute: https://a16z.simplecast.com/episodes/the-cost-of-compute

AI Revolution: Disruption, Alignment, and Opportunity: https://a16z.simplecast.com/episodes/ai-revolution-disruption-alignment-and-opportunity

The Robot Lawyer Resistance; https://a16z.simplecast.com/episodes/the-robot-lawyer-resistance

The Quest for AGI: Q*, Self-Play, and Synthetic Data: https://a16z.simplecast.com/episodes/the-quest-for-agi-q-self-play-and-synthetic-data

The Road to Autonomous Vehicles: Are We There Yet?: https://a16z.simplecast.com/episodes/the-road-to-autonomous-vehicles-are-we-there-yet-PstZz2G_

The Electrification of Everything: From Sky to Sea: https://a16z.simplecast.com/episodes/the-electrification-of-everything-from-sky-to-sea

When Two Giants Intersect: Healthcare Meets Fintech: https://a16z.simplecast.com/episodes/when-two-giants-intersect-healthcare-meets-fintech

Salary Transparency: Clarity or Chaos?: https://a16z.simplecast.com/episodes/salary-transparency-clarity-or-chaos

Disrupting the World’s Largest Asset Class with Adam Neumann: https://a16z.simplecast.com/episodes/disrupting-the-worlds-largest-asset-class

The Data Highway Above with Privateer’s Steve Wozniak, Alex Fielding, and Dr. Moriba Jah: https://a16z.simplecast.com/episodes/new-the-data-highway-above-with-privateers-steve-wozniak-alex-fielding-and-dr-moriba-jah

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Welcome to “The Ben & Marc Show”, featuring a16z’s co-founders Ben Horowitz and Marc Andreessen.  In this week’s episode, Marc and Ben are joined by special guest Tony Robbins to discuss the future of longevity.  

Tony Robbins is an entrepreneur, #1 NY Times bestselling author, philanthropist, and the nation’s #1 life & business strategist.  For over four and a half decades, Tony has empowered more than 50 million people from 100 countries around the world through his audio programs, educational videos, and live seminars. He’s also the author of six international bestsellers, including “Money: Master the Game” (2014), “Unshakable: Your Financial Freedom Playbook” (2017) and “Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life and Those You Love” (2022).

Joined by a16z’s own Dr. Vijay Pande, PhD – General Partner since 2014, and founder and leader of a16z Bio + Health – the group discusses new breakthroughs in regenerative medicine, AI, biohacking, gene editing, mindset and confirms why this might be the best time to be alive. Enjoy!

Watch the full video version of this episode: https://youtu.be/V8h11baC_ok

Resources:

Marc on X: https://twitter.com/pmarca

Marc’s Substack: https://pmarca.substack.com/

Ben on X: https://twitter.com/bhorowitz

Dr. Vijay Pande on X: https://twitter.com/vijaypande

Learn more about Tony Robbins: https://tonyrobbins.com

Tony’s Time to Rise Summit (Jan 25-27, 2024): https://timetorisesummit.com/join-now  

Pre-order Tony’s upcoming book “The Holy Grail of Investing” (Feb 2024): http://theholygrailofinvesting.com

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

A new age of maritime exploration, the rise of the developer as a buyer in financial services, and more applications for computer vision and video intelligence. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024.

Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?

Topics Covered:

00:00 - Big Ideas in Tech 2024

01:39 -  Big Idea: The Rise of the Developer as a Buyer in Financial Services

07:03 - Examples of financial service infrastructure products

08:40 - Building products and cost/selling structures

09:56 - How financial institutions will adopt new technology

13:07 - Regulatory shifts and updates

14:09 - The impact on customers

16:30 - Big Idea: A New Age of Maritime 

18:15 - The challenges of maritime exploration 

19:56 - Why is 2024 the year of iInnovation in maritime exploration?

23:32 - Space and aerospace exploration’s impact on maritime 

26:51 - Geopolitical supply chain and climate applications

29:40 - Autonomous fleets

31:49 - Key challenges in modernizing maritime 

34:11 - Opportunities for builders in the space

36:23 - Big Idea: New Applications for Computer Vision and Video Intelligence

38:06 - The current use of video and it’s data

38:53 - The unlocks in hardware and software driving change

41:40 - Emerging applications and use cases

43:20 - Video and privacy

44:49 - Why is 2024 the year of change and innovation?

Resources:

Find Angela on Twitter :https://twitter.com/astrange

Find Grant on Twitter: https://twitter.com/grant__gregory

Find Kimberly on Twitter: https://twitter.com/kimberlywtan

View all 40+ big ideas: https://a16z.com/bigideas2024

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

General Partner Anjney Midha explores the cutting-edge world of text-to-video AI with AI researchers Andreas Blattmann and Robin Rombach. 

Released in November, Stable Video Diffusion is their latest open-source generative video model, overcoming challenges in size and dynamic representation.

In this episode Robin and Andreas share why translating text to video is complex, the key role of datasets, current applications, and the future of video editing.

Topics Covered: 

00:00 - Text to Video: The Next Leap in AI Generation

02:41 - The Stable Diffusion backstory

04:25 - Diffusion vs autoregressive models

06:09 - The benefits of single step sampling

09:15 - Why generative video?

11:19 - Understanding physics through AI video

12:20 - The challenge of creating generative video

15:36 - Data set selection and training

17:50 - Structural consistency and 3D objects

19:50 - Incorporating LoRAs

21:24 - How should creators think about these tools?

23:46 - Open challenges in video generation 

25:42 - Infrastructure challenges and future research 

Resources: 

Find Robin on Twitter: https://twitter.com/robrombach

Find Andreas on Twitter: https://twitter.com/andi_blatt

Find Anjney on Twitter: https://twitter.com/anjneymidha

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Voice-First Apps, AI Moats, Never-Ending Games, and Anime. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024.

Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?

Timecodes:

00:00 - Big Ideas in Tech 2024

01:39 - Big Idea: Voice-First Apps Will Become Integral to Our Lives

04:14 - The limiting factors of voice technology

05:27 - What would a voice-first app look like? 

06:52 - Voice tech for companionship and productivity 

08:05 - The primary modality voice applications

10:08 - How builders and founders can integrate voice technology

13:31 - Big Idea: The Consumer AI Battleground Moves from Model to UX

15:49 - How user experience can contribute toward building a moat

17:57 - The commoditization of models

19:55 - How should builders differentiate between model and experience?

22:58 - Breakout examples for 2024

25:10 - Open source vs closed source

26:44 - The impact of applications splitting from the infrastructure layer

28:14 - Big Idea: AI-First Games That Never End

29:59 -Generative AI in gaming and AI native games

31:12 - Introducing generative agents as game companions 

33:57 - Does the gaming community want hyper personalization?

38:00 - New entrants vs the incumbents

41:57 - How business models and cost structures are evolving

46:21 - Advice for game builders in 2024

48:03 - Big Idea: Anime Games Go Mainstream

49:28 - What defines anime?

52:05 - Anime’s monetization strategy and how it differs from other genres

54:04 - Why are we seeing a rise in anime?

55:56 - What is required to be successful in anime

58:20 - AI, XR and inventing the next wave of anime

Resources:

View all 40+ big ideas: https://a16z.com/bigideas2024

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Arthur Mensch is the co-founder of Mistral and the co-author of Deepmind’s pivotal 2022 "Chinchilla" paper.

In September 2023, Mistral released Mistral-7B, an advanced open-source language model that has rapidly become the top choice for developers. Just this week, they introduced a new mixture of experts model – Mixtral — that’s already generating significant buzz among AI developers.

As the battleground around large language models heats up, join us for a conversation with Arthur as he sits down with a16z General Partner Anjney Midha. Together, they delve into the misconceptions and opportunities around open source; the current performance reality of open and closed models; and the compute, data, and algorithmic innovations required to efficiently scale LLMs.

Resources:

Find Arthur on Twitter: https://twitter.com/arthurmensch

Find Anjney on Twitter: https://twitter.com/anjneymidha

Learn more about Mistral: https://mistral.ai

Learn why we invested in Mistral: https://a16z.com/announcement/investing-in-mistral/

Stay Updated: 

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Smart energy grids. Voice-first companion apps. Programmable medicines. AI tools for kids.
We asked over 40 partners across a16z to preview one big idea

they believe will drive innovation in 2024.

Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?

View all 40+ big ideas: https://a16z.com/bigideas2024

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One topic at the center of the AI universe this week is a potential breakthrough called Q*. Little has been revealed about this OpenAI project, other than its likely relationship to solving certain grade-school mathematical problems.

Amid much speculation, we decided to bring in our new general partner, Anjney Midha – focused on all things AI – to sift through the sea of noise.

Today, we discuss the key frontier research areas that AI labs are exploring on their path toward generalizable intelligence, from self-play, to model-free reinforcement learning to synthetic data. Anjney also shares his insights on which approach he expects to be most influential in the next wave of LLMs and why math problems are even a suitable testing ground for this kind of research.

Topics Covered:

02:03 - What is Q*?

06:21 - Applying model-free reinforcement learning to complex spaces

13:17 - The role of self-play

19:04 - Synthetic data’s big unlock

24:44 - What does this unlock for society?

Resources:

Follow Anjney on Twitter: https://twitter.com/AnjneyMidha

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @davidmarcus @smc90

This wide-ranging conversation covers company building, big to small -- including what cadence and when is the right "time" to ship; the relationship between centralization, decentralization, platforms, and financial freedom; moving from web2 to web3 in both crypto AND payments... as well as why bitcoin, views on remote work, and much much more. 

Our guest is David Marcus, CEO and co-founder of Lightspark; Marcus was also a co-creator of Diem (aka Libra and Novi, the cryptocurrency project initiated by Facebook). Before that, he was vice president of messaging products there, where he ran the Facebook Messenger unit; and prior to joining Facebook, Marcus was the former president of PayPal (which had acquired his previous startup).  

This episode begins with an interview just to help kick things off and then features a rich set of questions from the audience -- as this originally took place live on stage at our Crypto Startup School 2023. 

As a reminder: none of this should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.

related readings:

• Regulate apps, not protocols series (2022-2023) - Miles Jennings et al, a16z crypto)
• What it will take to create the next great Silicon Valleys (2014) - Marc Andreessen (Politico, a16z)
• Why bitcoin matters (2014) - Marc Andreeessen (NYT, a16z)
• When one app rules them all: The case of WeChat and Mobile in China (2015) - Connie Chan (a16z)

Subscribe to web3 with a16z: https://link.chtbl.com/web3witha16z

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Taking a company from idea to household name is always difficult. But the past few years presented challenges that caught even the most-seasoned CEOs off guard.

In this episode, you’ll hear from two CEOs that navigated these waters and somehow, came out on the other side. These recordings come straight from our exclusive Connect/Enterprise event, bringing together top executives across the a16z network.

Resources:

Additional content from Connect/Enteprise:

• Enterprise Startups: Advice on Hiring, Firing, Scaling, and Selling
• Building Products With Generative AI
   

Learn more about company-building: https://a16z.com/category/company-building/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Fei-Fei Li, PhD,  Professor in the Computer Science Department at Stanford University, and Co-Director of Stanford’s Human-Centered AI Institute, joins Bio + Health founding partner Vijay Pande.

In this candid conversation, Li unfolds her transformation from a young immigrant to an influential figure in AI. The conversation explores the birth of ImageNet, a pivotal step that bridged the gap between visual intelligence and accessible AI technology. They delve into the notion of a 'Dignity Economy,' hinting at a future where technology serves to elevate human experience rather than undermine it. Li also touches on the delicate balance between relentless innovation and life's humble pursuits. This episode peels back the layers on the human side of AI, offering a rare glimpse into the personal and professional realms of a pioneer shaping the AI landscape.

Check out her new book, The Worlds I See, here: https://us.macmillan.com/books/9781250897930/theworldsisee

Check out other episodes form our sister podcast, Bio Eats World: https://a16z.com/podcasts/bio-eats-world/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Is it possible to construct a virtual society that authentically replicates human behavior? AI Town, a virtual town experiment where AI residents live, interact, and engage, provides valuable insights into the future of AI's believability and its interaction with humanity.

In this panel discussion, Joon Park, the author of 'Generative Agents: Interactive Simulacra of Human Behavior,' and Martin Casado from a16z, discuss  the influence and potential of Generative Agents, exploring their practical applications in the real world.

Topics Covered

00:00 - Simulating human behaviors

04:49 - What are generative agents?

07:47 - Simulations, new technology, and LLMs

11:45 - The architecture behind simulating human behavior

16:37 - Generative agents interactions: observing, planning, and reflecting

20:22 - What is the value in advancing generative agents?

24:01 - Use cases for simulation behavior technology

29:31 - What are the ethical frameworks?

33:12 - Q&A from the audience 

Resources: 

Find AI Town: https://www.convex.dev/ai-town

Read the paper ‘Generative Agents: Interactive Simulacra of Human Behavior’: https://arxiv.org/pdf/2304.03442.pdf

Find Joon on Twitter: https://twitter.com/joon_s_pk

Find Martin on Twitter: https://twitter.com/martin_casado

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Software crosses borders effortlessly. The globalization of money, however, is considerably more challenging. This is especially true for multinational businesses, which grapple with managing multiple accounts in diverse currencies, navigating costly foreign exchange rates, and unpredictable money transfers.

As businesses increasingly embrace a global default, top fintech entrepreneurs are rising to the challenge, addressing cross-border infrastructure issues and offering comprehensive solutions.

In this episode, a16z partners Angela Strange, Joe Schmidt, and Gabriel Vasquez discuss the challenges of cross-border payment infrastructures and what fintech entrepreneurs are doing to create a more integrated, financially inclusive world.

Topics Covered:

00:00 - Software crosses borders easily; money does not. 

03:02 - Why has global payments been a challenge for so long? 

05:44 - How global payments and money currently moves

07:25 - The metrics used to measure a country's financial health

12:13 - The impact of regulation on financial services

16:23 - Can the same regulations be applied to any country? 

21:29 - Why each country has its own fintech system

24:54 - Opportunities in global payments infrastructure

34:47 - Advice for founders navigating global fintech systems

36:58 - What does a truly global system enable? 

Read the Fintech Fuels Global Payments package: https://a16z.com/global-payments

Watch ​​’Foreign Exchange 101: What Happens When You Send Money Abroad?’: https://youtu.be/eoXdyO9oGJc?feature=shared

Find Angela on Twitter: https://twitter.com/astrange

Find Joe Schmidt on Twitter: https://twitter.com/joeschmidtiv

FInd Gabriel Vasquez on Twitter: https://twitter.com/GEVS94

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Subscribe to The Ben & Marc Show on Apple Podcasts: https://bit.ly/3SdsfNt

Subscribe to The Ben & Marc Show on Spotify: https://spoti.fi/3SclPOr

Read the full manifesto: https://a16z.com/the-techno-optimist-manifesto/

This past week, Marc released his new vision for the future – “The Techno-Optimist Manifesto”.

In an article that has sparked widespread conversation across traditional and social media, Marc challenges the pessimistic narrative surrounding technology today, and instead celebrates it as a liberating force that can lead to growth, progress and abundance for all. In this one-on-one conversation based on YOUR questions from X (formerly Twitter), Ben and Marc discuss how technological advancements can improve the quality of human life, uplift marginalized communities, and even encourage us to answer the bigger questions of the universe.

We hope you’ll be inspired to join us in this Techno-Optimist movement. Enjoy!

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As VR technology inches forward, completely new experiences loom on the horizon.

In today’s episode, we expose listeners to the very real-world use cases already present on these devices, from fitness to education.

First up is Gym Class VR, one of the top-rated apps on the Quest. Cofounder, Paul Katsen, shows us how to dribble and dunk in the metaverse, but more importantly, discusses the social impact of VR, the technological prerequisites to get there, and the role of AI as we progress.

Following on is a founder on a mission to revolutionize education. Anurupa Ganguly from Prisms VR, explores how virtual reality has the potential to close the gap – one where 70% of US 8th graders are not proficient in foundational math.

Head over to our YouTube channel to see two a16z Podcast firsts: a full interview in VR, and host Steph slam dunking on an NBA court. 

Topics Covered: 

00:00 - The current state of VR

03:38 - How do you build the #1 VR app?

05:56 - How will VR become an everyday activity?

07:37 - The social and the technical arc of VR

11:47 - Untapped opportunities in VR

13:24 - Integrating AI into VR

17:09 - Prisms VR

20:10 - Why it’s critical to fix America’s math problem

21:12 - Why put VR in classrooms now?

23:23 - The successes of VR in the classroom

26:03 - Stats from the impact report

27:44 - Other curriculums could benefit from VR 

31:04 - Opportunities for AI in VR

Resources:

• Find Paul on Twitter: https://twitter.com/pavtalk
• Learn more about Gym Class: https://www.gymclassvr.com
• Find Gym Class in Meta Quest: https://www.meta.com/experiences/3661420607275144/
• Find Anurupa on LinkedIn: https://www.linkedin.com/in/anurupa-ganguly-92790379
• Learn more about Prisms VR: https://www.prismsvr.com

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear directly from a16z cofounder Ben Horowitz and Databricks cofounder and CEO, Ali Ghodsi as they answer questions around AI and the enterprise, plus their perspectives on open source, whether benchmarks are BS, and the scramble of universities to take part in the very wave they kicked off decades ago.

If you’d like to access all the talks from AI Revolution in full, visit a16z.com/airevolution.

Resources:

• Find Ali on Twitter: https://twitter.com/alighodsi
• Find Ben on Twitter: https://twitter.com/bhorowitz
• Check out Databricks: https://twitter.com/databricks

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear a16z Bio & Health GP Vijay Pande speak with Daphne Koller about the fascinating convergence of machine learning and genomics – two industries that have benefitted decades of investment and progress – which are now colliding head on.

Daphne is a prominent innovator at this intersection, as a long-time professor in computer science at Stanford and co-founder of Coursera, who has decided to step back into the arena with her company Insitro. In fact, Insitro is a blend of in silico and in virto!

If you’d like to access all the talks from AI Revolution in full, visit a16z.com/airevolution.

Resources:

• Find Daphne on Twitter: https://twitter.com/DaphneKoller
• Find Vijay on Twitter: https://twitter.com/vijaypande
• Find Insitro on Twitter: https://twitter.com/insitro

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear discussion around the real-world impact of this revolution, on industries ranging from gaming to design, and the considerations around alignment along the way.

This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution.

Topics Covered:

00:00 - AI Revolution

02:39 - Putting technology in users’ hands

08:21 - AI alignment and safety

21:44 - Future opportunities

Resources: 

Catch the all the talks at https://a16z.com/airevolution

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear about the economics of AI, broad vs specialized models, the importance of UX, and whether we can expect scaling laws to continue.

This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution.

Topics Covered

00:00 - AI Revolution

01:42 - The economics of AI

06:55 - The third epoch of compute

13:52 - Recognizing scaling laws

17:42 - Can scaling laws continue?

22:34 - Potential bottlenecks

25:58 - Personalization vs generality

29:43 - The importance of UX

31:55 - The future of multi-modality

Resources:

Catch the all the talks at https://a16z.com/airevolution

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The space industry is evolving rapidly, with the cost of launching payloads to orbit dropping significantly. But who's investing in this sector, and how will it evolve? 

In this episode, we delve into the transformative journey of the satellite industry with Andy Lapsa, co-founder of Stoke Space. With over a decade of experience at Blue Origin, Andy is now at the forefront of sustainable space travel, pioneering fully reusable rockets.

Don’t forget to check out Part 1 in this mini series, where we explore the public and private players in space with John Gedmark from Astranis.

Resources: 

Learn more about Stoke: https://www.stokespace.com

Find Andy on Twitter: https://x.com/AndyLapsa?s=20

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The cost of launching payloads to orbit has dramatically dropped, igniting a space renaissance. In 2022, a record 186 rocket launches (41 more than the previous year!) underscores this shift.

In Part 1 of our satellite economy mini-series, we sit down with John Gedmark, co-founder of Astranis, to reflect on today's innovations, who’s on the other side of the satellite market, the capabilities they’re looking for, competition, and their mission to provide internet access to 4 billion underserved people.

Look out for Part 2, where we tackle the challenges of rapidly reusable rockets with Andy Lapsa from Stoke Space.

Resources: 

Learn more about Astranis: https://www.astranis.com

Find John on Twitter: https://x.com/Gedmark?s=20

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @alive_eth @danboneh @smc90

This week's all-new episode covers the convergence of two important, very top-of-mind trends: AI (artificial intelligence) & blockchains/ crypto. These domains together have major implications for how we all live our lives everyday; so this episode is for anyone just curious about, or already building in the space. 

The conversation covers topics ranging from deep fakes, bots, and the need for proof-of-humanity in a world of AI; to big data, large language models like ChatGPT, user control, governance, privacy and security, zero knowledge and zkML; to MEV, media, art, and much more. Our expert guests (in conversation with host Sonal Chokshi) include: 

• Dan Boneh, Stanford Professor (and Senior Research Advisor at a16z crypto), a cryptographer who’s been working on blockchains for over a decade and who specializes in cryptography, computer security, and machine learning -- all of which intersect in this episode;
• Ali Yahya, general partner at a16z crypto, who also previously worked at Google -- where he not only worked on a distributed system for a fleet of robots (a sort of "collective reinforcement learning") but also worked on Google Brain, where he was one of the core contributors to the machine learning library TensorFlow built at Google.

The first half of the hallway-style conversation between Ali & Dan (who go back together as student and professor at Stanford) is all about how AI could benefit from crypto, and the second half on how crypto could benefit from AI... the thread throughout is the tension between centralization vs. decentralization.  So we also discuss where the intersection of crypto and AI can bring about things that aren't possible by either one of them alone...

pieces referenced in this episode/ related reading:

• The Next Cyber Reasoning System for Cyber Security (2023) by Mohamed Ferrag, Ammar Battah, Norbert Tihanyi, Merouane Debbah, Thierry Lestable, Lucas Cordeiro
• A New Era in Software Security: Towards Self-Healing Software via Large Language Models and Formal Verification (2023) by  Yiannis Charalambous, Norbert Tihanyi, Ridhi Jain, Youcheng Sun, Mohamed Ferrag, Lucas Cordeiro
• Fixing Hardware Security Bugs with Large Language Models (2023) by Baleegh Ahmad, Shailja Thakur, Benjamin Tan, Ramesh Karri, Hammond Pearce
• Do Users Write More Insecure Code with AI Assistants? (2022) by Neil Perry, Megha Srivastava, Deepak Kumar, Dan Boneh
• Asleep at the Keyboard? Assessing the Security of GitHub Copilot's Code Contributions (2021) by Hammond Pearce, Baleegh Ahmad, Benjamin Tan, Brendan Dolan-Gavitt, Ramesh Karri
• Voting, Security, and Governance in Blockchains (2019) with Ali Yahya and Phil Daian   
   

As a reminder: none of the following should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including to a link to a list of our investments – especially since we are investors in companies mentioned in this episode.

Stay Updated: 

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With recent landmark legislation being passed around salary transparency, many companies are playing catch up as they interpret and implement changes.

In this episode, members of the a16z People Operations team,  Shannon Schiltz and Brandon Cherry explore how companies can best prepare themselves to not just survive, but thrive in this new environment.

Topics Covered:

00:00 - Salary transparency legislation

01:52 - The culture around pay transparency 

03:39 - What is the legislation?

07:01 - How are companies reacting?

11:03 - Structuring a compensation philosophy 

12:30 - Pay ranges

15:35 - Exceptions to the pay range

18:17 - Leveling staff

22:30 - Ranges and roles and company growth

28:24 - Location based pay

30:05 - What should employees look for when applying for work?

32:19 - Job postings

35:05 - Reviewing compensation ranges 

35:42 - At what stage do you hire help?

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

How many people spend more time organizing their “second brains”, instead of leveraging the information within them? 

With consumer AI now capable of processing simple language prompts and interfacing with unstructured data, is the landscape of information management on the brink of a transformative evolution?

Founders of Mem, Kevin Moody and Dennis Xu, plus writer Nat Eliason, explore what’s gotten in the way of a true second brain, and how AI may finally unlock what “knowledge management” tools have promised for so long. 

Topics Covered:

00:00 - A true second brain

02:45 -  Knowledge management

06:01 - Thiago Forte's ‘Building a Second Brain’

10:24 - Digital hoarding

12:53 - The fun of organizing 

14:16 - Levels of utility

19:09 - Can the unstructured nature of AI help?

21:46 - What does a second brain unlock? 

25:23 - Time spent  searching for information

31:07: LLMs and technology unlocks

34:22 - Personalization 

36:24 - Is the second brain a new PA and EA?

38:57 - Challenges

44:32 - Moats and differentiators 

Resources:

• Link to Mem’s website: https://mem.ai
• Find Kevin on Twitter: https://twitter.com/kevinfmoody
• Find Dennis on Twitter: https://twitter.com/DennisHXu
• FInd Nat on Twitter: https://twitter.com/nateliason
• Nat’s course on Effortless Output in Roam: https://www.effortlessoutput.com/

Stay Updated: 

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. They discuss everything from the inspiration behind Ben’s book The Hard Thing About Hard Things, how the open Internet was secured, the difference between wartime and peacetime CEOs, scaling culture, and understanding how bio & healthcare differs from other forms of technology.

Topics Covered:

00:00 - Introduction

02:09 - What are the most important lessons for a CEO?

08:45 - Surprising leaders in history

11:41 - Wartime CEO vs the peacetime CEO

14:54 - Cultures role

20:59 - Communication and scaling 

25:39 - Culture as a moat

27:46 - The interplay between startups and incumbents

30:22 - Advice for founders on navigating AI

Resources:

• Find Ben on Twitter: https://twitter.com/bhorowitz
• Find Jorge on Twitter: https://twitter.com/jorgecondebio
• Ben’s Book: https://www.amazon.com/Hard-Thing-About-Things-Building/dp/0062273205

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From artificial limbs to memory foam, many inventions have emerged from our quest to understand the cosmos. 

In this episode we explore cosmic history, space's impact on technology, and the enduring human fascination with space exploration. To take us on this journey is astrophysicist John Mather, a Nobel Prize winner for his work on the COBE satellite and a key figure in the James Webb Space Telescope project.

Prepare to be intrigued and left with a sense of wonder about the universe's influence on our world.

Topics Covered:

00:00 –  Innovations through the pursuit of space

03:52– John’s early life 

06:44 – Proving The Big Bang Theory 

13:30 – The mysteries of quantum mechanics

15:10 –  Leading the James Webb Telescope

17:12 – Images from James Webb

20:32 – Are we alone? 

24:20 – New telescopes

25:18 – Engineering in space for earth

29:31 –  What would you like to see solved in your lifetime?

32:24 – What came before The Big Bang? 

25:04 – Misconceptions about space

37:17 – Can humans be a multiplanetary species?

38:20 - Private vs public spending in space

40:24 – What’s the future of space exploration?

Resources:

• COBE satellite imagery: https://www.nasa.gov/topics/universe/features/cobe_20th.html
• Images from the James Webb Telescope: https://webbtelescope.org/images
• Exoplanet transmission spectrum: https://webbtelescope.org/contents/media/images/2022/032/01G72VSFW756JW5SXWV1HYMQK4

Stay Updated: 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain

With students learning in more places and different ways than we have ever seen, the pace of change in education is dizzying. Can this progress narrow learning gaps exacerbated by COVID-19 or will it fuel divides? How can we make the most of this once-in-a-generation opportunity?

Join our panelists from Khan Academy, PrismsVR, and Minecraft Education as we discuss the classroom of the future, and how important technologies including AI, XR, and gaming should play a role in it.

Topics Covered:

00:00 – The classroom of 2023

04:30 – Data on the current classroom

05:40– Developing the next gen of STEM talent

08:00 –  AI in the classroom 

13:10 – The role of gaming in the classroom

16:00 – Misconceptions of technology in classroom

17:51 – The ways teachers and students use AI

21:15 - The future role of a teacher

24:25 – Personalization and ownership in education

27:11 – Getting hardware into the classroom

29:54 - Misconceptions of teacher’s abilities and appetite for tech

31:25 – Why implement these changes now?

36:05 – Call to action for the classroom of 2050

Resources:

• Find Sal Khan on Twitter: https://twitter.com/salkhanacademy
• Find Romy Drucker on Twitter: https://twitter.com/romydrucker
• Find Allison Matthews on LinkedIn: https://www.linkedin.com/in/allison-matthews-4050677/
• Find Anurupa on LinkedIn: https://www.linkedin.com/in/anurupa-ganguly-92790379/
• Learn more about Khan Academy: https://www.khanacademy.org/
• Learn more about The Walton Family Foundation: https://www.waltonfamilyfoundation.org/
• Learn more about Minecraft Education: https://education.minecraft.net/en-us
• Learn more about Prisms VR: https://www.prismsvr.com/
• Watch more panel discussions from The Aspen Ideas Festival 2023: https://www.aspenideas.org/

Stay Updated: 

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With software becoming more important than ever, hardware is following suit.

As the world generates more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware. 

But how much does this all really cost? In this final segment of our AI hardware series, we tackle that question head on. 

Be sure to check part 1 and 2, where we explore the emerging architectures and the momentous competition for AI hardware.

Topics Covered:

00:00 – The cost of compute

02:20 – Is this sustainable?

03:23 – The cost to train a model

05:39 – Computation requirements

09:05  – The relationship between compute, capital, and technology

11:15 – GPT4 commenting on the technology with help from ElevenLabs

Resources: 

• Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/
• Find Guido on Twitter: https://twitter.com/appenz

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With the world constantly generating more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware.

In this episode – the second in our three-part series – we explore the challenges for founders trying to build AI companies. We dive into the delta between supply and demand, whether to own or rent, where moats can be found, and even where open source comes into play.

Look out for the rest of our series, where we dive into terminology and technology that is the backbone of the AI, how much the cost of compute truly costs!

Topics Covered:

00:00 – Supply and demand

02:44 –  Competition for AI hardware

04:32– Who gets access to the supply available

06:16– How to select which hardware to use

08:39– Cloud versus bringing infrastructure in house

12:43– What role does open source play? 

15:47– Cheaper and decentralized compute

19:04– Rebuilding the stack

20:29– Upcoming episodes on cost of compute

Resources: 

• Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/
• Find Guido on Twitter: https://twitter.com/appenz

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2011, Marc Andreessen said, “software is eating the world.” And in the last year, we’ve seen a new wave of generative AI, with some apps becoming some of the most swiftly adopted software products of all time.

So if software is becoming more important than ever, hardware is following suit. In this episode – the first in our three-part series – we explore the terminology and technology that is now the backbone of the AI models taking the world by storm. We’ll explore what GPUs are, how they work, the key players like Nvidia competing for chip dominance, and also… whether Moore’s Law is dead?

Look out for the rest of our series, where we dive even deeper; covering supply and demand mechanics, including why we can’t just “print” our way out of a shortage, how founders get access to inventory, whether they should own or rent, where open source plays a role, and of course… how much all of this truly costs!

Topics Covered:

00:00 – AI terminology and technology

03:44 - Chips, semiconductors, servers, and compute

04:48 - CPUs and GPUs

06:07 - Future architecture and performance

07:01 - The hardware ecosystem

09:05 - Software optimizations

12:23 - What do we expect for the future?

14:35 - Upcoming episodes on market  and cost

Resources: 

• Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/
• Find Guido on Twitter: https://twitter.com/appenz

Stay Updated: 

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Despite the ease of product building, sustainable growth has become increasingly challenging as many traditional channels no longer deliver the same results.

In these challenging times, we explore the remaining growth opportunities. How can we achieve a balance between efficiency, profitability, and growth? Which channels are still relevant and how can they be effectively mastered in 2023?

Join us as we discuss these questions with three seasoned experts who have successfully navigated similar confusing times in the past: Gina Gotthilf, leading Latitud and renowned for her impressive tenure as the VP of Growth at Duolingo; Kieran Flanagan, a long-time SVP of Marketing at HubSpot; and Bryan Kim, Consumer Partner at a16z, who held various leadership roles during Snap's hypergrowth phase up to its IPO.

Topics Covered:

00:00 – What growth opportunities exist in 2023?

03:00 – What still works in growth?

05:02 – The fundamentals and framework of growth

07:02 – Assessing growth potential and product lead growth

09:33 – Distribution

11:15 – Your moat and growth

14:00 – Integrating AI for product lead growth

16:23 –Trust as a moat

17:23 – B2C growth - discovery and breaking through

18:51 – Can you get ahead of the incumbents?

22:03 – Examples of companies and products

24:59 – How do you foster a growth culture?

28:38 – Experimentation  

34:20 – How companies using AI in distribution

44:43 – Growth challenge: What would you do with $10K?

Resources:

• Check out Latitud: https://go.latitud.com/
• Check out Zapier: https://zapier.com/
• Find Bryan on Twitter: https://twitter.com/kirbyman01
• Find Kieran on Twitter :https://twitter.com/searchbrat
• Find Gina on Twitter: https://twitter.com/ginag

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas Mavericks, one of the sharks on Shark Tank, and cofounder of the Mark Cuban Cost Plus Drug Company. He is joined by Vijay Pande, founding partner of a16z Bio + Health. 

Together, they talk market forces in healthcare, the importance of trust to patients, and Mark’s ideas to tackle the Gordian knot that is American healthcare.

Listen to our last two episodes on Healthcare x Fintech:

• When Two Giants Intersect: Healthcare Meets Fintech
• How Fintech is Reshaping Our $4T Healthcare Industry

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Remote work is a big, divisive topic right now. Some think it’s the future, while others think it was an experiment gone wrong.

But it’s also not the only way to attract top talent. And the equation for doing so has only gotten more confusion as a myriad of trends intersect, from layoffs to emerging technologies like AI.

So how can companies navigate this storm and truly attract the talent that matters? Listen in to find out.

Topics Covered:

• 00:00 – Introduction
• 03:26 – What it takes to attract top talent in 2023
• 06:36 – What employees really care about
• 14:13 – Positives and negatives of benefits
• 17:32 – Generational differences
• 27:44 – Will the return to office work?
• 34:35 – Differentiating through benefits
• 38:35 – Advice to attract top talent
• 44:16 – Closing thoughts

Resources:

• A-Team study referenced:https://www.a.team/mission/college-grads-survey
• iCIMS study referenced: https://www.dropbox.com/s/2q3hepreozaurte/iCIMS-Class-of-2021-Report.pdf
• Most recent iCIMS study: https://www.icims.com/wp-content/uploads/2022/08/iCIMS-2023-Workforce-Report-FINAL.pdf
• Find AJ on Twitter: https://twitter.com/ItsAJThomas
• Find Rob on Twitter: https://twitter.com/RobFrohwein
• Find Hung on Twitter: https://twitter.com/HungLee
• Check out Keep Financial: https://keepfinancial.com/
• Check out Recruiting Brainfood: https://www.recruitingbrainfood.com/

Self-driving cars have been on the horizon for quite some time. But, they might actually be here.

We got to ride around in one all over San Francisco with Waymo’s Chief Product Officer, Saswat Panigrahi.

We discussed so much, including the five levels of autonomy, the infamous LIDAR vs video debate, regulation, UX, and the role of AI in fine-tuning these models. But most importantly, if autonomy is here… now what?!

Topics Covered:

• 00:00 - Introduction
• 03:20 - A first look at Waymo
• 05:21 - 5 levels of autonomy
• 09:45 - Technology challenges
• 14:32 - LiDAR vs video debate
• 18:19 - How Waymo differentiates
• 19:01 - Technological unlocks on the horizon
• 20:39 - The role of AI in autonomous vehicles
• 25:37 - How Waymo views safety
• 32:05 - Collaborating with regulators
• 37:26 - Learnings from the first 2m miles
• 39:45 - Driving user retention
• 43:47 - Waymo’s expansion strategy
• 47:00 - Changing regulation
• 47:41 - Societal unlocks enabled by autonomy
• 52:21 - Will self-driving cars replace humans?
• 52:58 - Closing thoughts

Resources:

Check out Waymo: https://waymo.com/

Check out Waymo's Youtube channel: https://www.youtube.com/@Waymo

Find Saswat on Twitter: https://twitter.com/saswat101

Check out a16z's 8-part series on the autonomous vehicle ecosystem: https://a16z.com/2018/02/03/autonomy-ecosystem-frank-chen-summit/

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @skominers @smc90

In this deep dive and tour through key business concepts, from theory to practice, we cover the topics of strategy, competitive advantage,  network effects, moats, and more -- covering both both basic foundations, as well as the tricky nuances in a new world of open source, including web3.  In the first half of this discussion, we cover foundational business concepts and questions -- such as the nature of competition, and how it *really* changes in web3; as well as how network effects really work -- and then, in the second half (in case you want to skip ahead), we cover mindsets and general guidance for builders…

Our expert guest -- in conversation with editor in chief and host Sonal Chokshi -- is a16z crypto research partner Scott Duke Kominers, who is also a professor at Harvard Business School; a faculty affiliate in Harvard’s Department of Economics; and advises several companies on marketplace development, incentive design, and more; as well as advises, and is directly involved, in several NFT communities. 

Scott also teaches on these topics -- both at Harvard and also recently at our Crypto Startup School -- so be sure to subscribe to our playlist for those talks on the a16z crypto YouTube channel to get the latest updates as we release more videos from the 2023 cohort.  

Listen to web3 with a16z: https://web3-with-a16z.simplecast.com/

related links // see also:

• Can web3 bring back competition to digital platforms? by Christian Catalini and Scott Duke Kominers
• Why build in web3 by Jad Esber and Scott Duke Kominers
• Vampire attacks: A theory (and thread) on 'blood sucking' platform competition by John William Hatfield and Scott Duke Kominers
• Why NFT creators are going cc0 by Flashrekt and Scott Duke Kominers
• Decentralized identity: Your reputation travels with you by Scott Duke Kominers and Jad Esber
• Increasing returns and the new world of business (1996) by W. Brian Arthur
• Network effects, origin Stories, and the evolution of tech with W. Brian Arthur, Marc Andreeessen, and Sonal Chokshi
• The five competitive forces that shape strategy (2008 reformulation of 1979 paper) by Michael Porter
• Strategies for two-sided markets (2006) by Tom Eisenmann, Geoffrey Parker, and Marshall Van Alstyne

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.