October 2026: The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions

Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics.

• 00:42 Conway interview
• 02:34 Quality of life
• 05:13 Ethical considerations of a sham arm in this population
• 07:00 Timing and VNS treatment
• 08:03 Clinical implications
• 09:02 Limitations
• 10:12 Further research
• 11:30 McDonald and Kalin interview
• 13:50 Song et al.
• 14:08 Li et al.
• 15:44 Donnery et al.
• 16:38 Valiengo et al.
• 17:28 Rush
• 20:03 Mahmoudi
• 22:37 Conway et al.

Transcript

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.

Subscribe to the podcast here.

Listen to other podcasts produced by the American Psychiatric Association.

Browse articles online.

How authors may submit their work.

Follow the journals of APA Publishing on Twitter.

E-mail us at [email protected]