Uncertainty and the art of systematic over-simplification

With the exponential expansion of the evidence base and increasing frequency of meta-analysis, clinical guidelines have become increasingly ubiquitous in all fields of medicine. Dr Georgina Imberger joins Dr Thomas to talk through the process of guideline generation from a developer's perspective, and question the way in which practising clinicians should apply wide-reaching recommendations to individual patients. Dr Imberger describes how a guideline is generated from clinical question through to recommendation, detailing the various stages and lending her unique insight into their relative degrees of reproducibility and subjectivity.