Bone marrow failure related to ERG insufficiency, factor 11 in vascular hyperpermeability, and new criteria for evaluating anemia in myelofibrosis

In this week's episode we’ll learn more about the role of ERG loss-of-function variants in bone marrow failure and hematological malignancies, a proposed pathway linking factor 11 activation to increased vascular permeability during inflammation, and new clinical criteria for diagnosing anemia, defining transfusion-dependence, and evaluating anemia treatment responses in patients with myelofibrosis.

Featured Articles:

• Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition
• Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo
• Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis