The Mushroom That Makes You See "Little People"

For nearly a century, reports of a mysterious psychoactive bolete have puzzled ethnomycologists and anthropologists alike. From the 1930s reports of "mushroom madness" in the highlands of Papua New Guinea, which drew the curiosity of R. Gordon Wasson, Roger Heim, and Albert Hofmann, to modern Yunnan, China, where accidental poisonings from undercooked culinary mushrooms cause people to reliably see visions of tiny, colorfully dressed "little people." In this episode of The Brainforest Café, Dennis McKenna sits down with mycologist and PhD candidate Colin Domnauer (University of Utah) to discuss how modern genomics, natural product chemistry, and fieldwork cracked this long-standing mystery. Colin shares his journey traveling to the markets and forests of Southwest China and the Philippines, using DNA sequencing to identify the primary species responsible (Lanmaoa asiatica), conducting groundbreaking rodent bioassays, and exploring what these non-psilocybin compounds could reveal about the neurobiology of perception and the cross-cultural phenomenon of Lilliputian hallucinations.

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Colin is a Bay Area California native whose research focuses on unravelling the ethnomycological mystery of psychoactive bolete mushrooms. With a lifelong interest and undergraduate degree in astronomy before changing his studies to the ethnobiology of psychoactive substances, Colin has always felt attracted to explore the mind-bending wonders of nature. In his free time, he enjoys engaging in just about any outdoor activity with friends, most of all foraging for mushrooms.

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