A Closer Look At Lecanemab Donanemab And Amyloid

In this podcast Dr Anna Volkmer, convenes a panel of world-renowned experts from University College London. They discuss the discovery of amyloid and its role in Alzheimer’s Disease and take an in-depth look into the latest developments surrounding Lecanemab and Donanemab, monoclonal antibodies (mAbs) as a treatment and Gene Silencing.

This week’s guests are Professor Sir John Hardy, Geneticist and trailblazer in neurodegenerative disease research, Professor Nick Fox, Neurologist, and eminent figure in the fields of neuroimaging and clinical neuroscience, and Dr Cath Mummery, Neurologist and leading light in cognitive disorders and clinical trials.

Listeners can expect:

• Discussion on new dementia drugs Lecanemab and Donanemab.
• Insights on the science behind these treatments, the story behind the discovery of amyloid and familial Alzheimer’s - with Carol Jennings.
• Clarification of misconceptions about dementia therapies.
• Information on the impact of these drugs on patients and clinical practice.
• A look at the future of dementia research, including gene-silencing therapies.

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• Alzheimer's Association Info on Research & Risks
• Alzheimer's Society Information on Lebanemab:
• Alzheimer's Society Information on Donanemab:
• NIA statement on donanemab results: More Alzheimer’s research progress:
• NIA statement on report of lecanemab reducing cognitive decline in Alzheimer’s clinical trial:

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A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk.

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We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research.

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