Researching Sanfilippo syndrome

In this weeks Dementia Researcher Podcast, we hear from Dr Karissa Barthelson, one of the latest Race Against Dementia Research Fellows from Flinders University – discussing her research, and specifically an introduction to Sanfilippo syndrome, a rare form of childhood dementia, and her research on this disease.

Regular Dementia Researcher Bloggers Dr Anna Volkmer & Dr Kamar Ameen-Ali lead the interview, helping us to understand Karissa’s work and exploring the science.

All types of neurodegenerative diseases share common molecular mechanisms responsible for disease etiology and progression. Karissa, is interested in understanding these shared mechanisms, as targeting the common problems could lead to new therapeutics to benefit more individuals who live with these diseases. To understand the shared molecular mechanisms, Karissa utilises zebra fish, as a model organism. Introducing mutations into zebrafish, equivalent to those which cause neurodegenerative diseases in humans (e.g., Alzheimer’s disease, Sanfilippo syndrome childhood dementia), then analysing their brains with very high molecular detail.

For more information about Sanfilippo syndrome visit – https://en.wikipedia.org/wiki/Sanfilippo_syndrome

For more information on Race Against Dementia visit – https://www.raceagainstdementia.com

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