From Meds to Meltdown: Understanding Stevens-Johnson and TEN

In this episode Dr. G explores Stevens-Johnson syndrome (SJS), a severe immune reaction where the skin and mucous membranes blister and peel, sometimes requiring burn-unit care. You’ll learn what triggers SJS—commonly medications—how it progresses along a spectrum to toxic epidermal necrolysis (TEN), and the key molecular and genetic factors involved.

The episode covers early flu-like warnings, diagnostic signs, complications like infection and vision loss, and why people with diabetes are at higher risk. Treatment priorities—stop the offending drug, intensive supportive care, wound management, and advanced therapies—are also explained.