155 - Applications of Flow Chemistry in Modern Drug Development (S11E5)

10 min • 24 maj 2025

This episode explores the increasing use of flow chemistry in the development and manufacturing of pharmaceutical products. The discussion begins by outlining what flow chemistry is, explaining how it involves performing chemical reactions inside a continuous stream, usually within narrow tubes or channels. The benefits of this approach are then explored. The core benefits of flow chemistry are safety, better control and scalable operations

The episode then explores some concrete examples of flow chemistry use, including the Barbier reaction for atomoxetine, and the preparation of isocyanates. Finally, the conversation turns to the broader implications of flow chemistry for the pharmaceutical industry. There is focus on how it contributes to efficiency, environmental friendliness, safety, and potentially faster development times. The episode concludes by speculating on the future of drug manufacturing, envisioning the possibility of small, modular, fully automated drug factories.