19- Fragment-Based Drug Discovery (S2E4)

This episode introduces the innovative approach of fragment-based drug discovery, where drugs are built piece by piece from small chemical fragments. We'll use the analogy of assembling a puzzle, comparing fragment screening with high-throughput screening (HTS). The discussion will also delve into the intricate details of protein-ligand interactions at the atomic level, providing insights from X-ray crystallography and NMR. Real-world literature examples from OPR&D sources will further illustrate the concepts.

We will also discuss the challenges of working with natural products, including their complexity, scarcity, and the difficulties of extraction. The resurgence of interest in natural product screening will be explored, highlighting the innovative ways scientists are combining traditional methods with cutting-edge technology. We'll also examine the ethical and environmental considerations surrounding the use of natural products in drug development. The episode will conclude with a discussion of the future of drug discovery, emphasizing the potential of AI and the importance of a balanced approach that combines the power of both natural products and synthetic libraries.