10.1.25 | Sora 2, Inflammation predicts heart disease over cholesterol, Imgur exits UK amid data fine threat

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• (00:00) - Intro
• (00:15) - Sora 2
• (01:25) - Inflammation now predicts heart disease more strongly than cholesterol
• (02:43) - Imgur pulls out of UK as data watchdog threatens fine
• (03:55) - Leaked Apple M5 9 core Geekbench scores
• (05:11) - Boeing has started working on a 737 MAX replacement
• (06:19) - CDC File Transfer
• (07:17) - Founder sentenced to seven years in prison for fraudulent sale to JPMorgan
• (08:34) - Designing agentic loops
• (09:48) - Diff Algorithms
• (10:45) - An opinionated critique of Duolingo
• (12:01) - Outro

Inflammation now predicts heart disease more strongly than cholesterol
https://www.empirical.health/blog/inflammation-and-heart-health/
https://news.ycombinator.com/item?id=45430498

Imgur pulls out of UK as data watchdog threatens fine
https://www.express.co.uk/news/uk/2115228/image-site-imgur-pulls-out
https://news.ycombinator.com/item?id=45424888

Leaked Apple M5 9 core Geekbench scores
https://browser.geekbench.com/v6/cpu/14173685
https://news.ycombinator.com/item?id=45427197

Boeing has started working on a 737 MAX replacement
https://www.wsj.com/business/airlines/boeing-has-started-working-on-a-737-max-replacement-40a110df
https://news.ycombinator.com/item?id=45428482

CDC File Transfer
https://github.com/google/cdc-file-transfer
https://news.ycombinator.com/item?id=45433768

Founder sentenced to seven years in prison for fraudulent sale to JPMorgan
https://www.cnn.com/2025/09/30/business/charlie-javice-frank-sentenced-jpmorgan-intl
https://news.ycombinator.com/item?id=45424827

Designing agentic loops
https://simonwillison.net/2025/Sep/30/designing-agentic-loops/
https://news.ycombinator.com/item?id=45426680

Diff Algorithms
https://flo.znkr.io/diff/
https://news.ycombinator.com/item?id=45430604

An opinionated critique of Duolingo
https://isomorphism.xyz/blog/2025/duolingo/
https://news.ycombinator.com/item?id=45425061