Immune 95: Mitochondria for everyone

Immune discusses how cancer cells swap mitochondria with T cells and then digs in for a discussion of an unusual checkpoint blockade that failed for cancer but could be repurposed for autoimmune inflammation.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• Cancer cells steal mitochondria from neurons for metastasis (Nature 2025)
• Cancer cells donate damaged mitochondria to T cells to impair them (Nature 2025)
• PD-L1 binding to CD80 on the same dendritic cell needed for migration (Sci Adv 2025)
• Time stamps by Jolene Ramsey. Thanks!

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Information on this podcast should not be construed as medical advice.