Bladder-Gut Dialogue: Unraveling the Interorgan Neuroimmune Circuit

A deep dive into a groundbreaking communication pathway between organs: how inflammation in the bladder can heighten gut sensitivity without inflammation in the colon, via a shared network of sensory neurons. We explore a mouse model of ICPS, LL37-induced bladder inflammation, constipation-like gut changes, and increased colonic sensitivity, then reveal how retrograde tracing uncovers dual bladder/colon neurons in dorsal root ganglia and how in vivo calcium imaging confirms their functional role. Join us as we unpack the implications for ICPS and IBS comorbidity and what this could mean for future therapies.

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