None of this is medical advice.
5 AM on a Saturday and I can’t go back to sleep. It's not the first time, so I get up to write, I might as well use the time I’m given. My hangover is to blame, even a little alcohol the night before changes my sleep cycle.
You’d think it would ruin my day, but in some ways I feel better. I’m more alert, more anxious, more motivated. It's like being more alive. Being more awake for only one day has me asking questions. Why did sleep evolve? Can we sleep less?
Why did sleep evolve?
Sleep evolved for temporal niches
Imagine you’re a Zebra. You need to eat a lot of grass to maintain your metabolism. To do so, you need to look around to find the best grasses. You also need to be able to [...]
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Outline:
(00:46) Why did sleep evolve?
(00:49) Sleep evolved for temporal niches
(03:54) Other evolutionary theories of sleep don't work
(07:51) Safe sleep need reduction is feasible
(09:38) Small molecule Orexin agonists
(12:31) Why has nobody done this before?
(13:58) Other benefits of sleep need reduction
(14:02) Curing other ailments
(15:08) Broader effects
(16:37) How this research could fail
(18:42) Conclusion
(19:38) Appendix
(19:41) Objections to sleep-need reduction.
(21:48) Other avenues for sleep reduction
(23:36) Other Treatments
(25:18) Why small molecule drugs are more promising
(27:33) Other links, companies, and related efforts
(27:39) Related efforts
(28:18) Companies working on Narcolepsy
(28:41) Papers
(31:15) Other links
(32:08) Pop-sci articles
The original text contained 8 footnotes which were omitted from this narration.
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First published:
May 21st, 2025
Source:
https://www.lesswrong.com/posts/Nmp6FWAj3mcuLu6H6/sleep-need-reduction-therapies-1
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Narrated by TYPE III AUDIO.
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Senaste avsnitt
En liten tjänst av I'm With Friends. Finns även på engelska.