Choosing Therapies for ATTR-CM in 2026

Drs Alexander and Urey walk through stabilizers vs silencers, pivotal trial data, and practical first line choices to help you select the right ATTR CM therapy for each patient.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-attr-cm-s1-ep6-2026a10006hh. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Transthyretin-Related Amyloidosis https://emedicine.medscape.com/article/335301-overview

Disease-Modifying Therapies for Amyloid Transthyretin Cardiomyopathy: Current and Emerging Medications https://pubmed.ncbi.nlm.nih.gov/39714070/

Therapy of Amyloidosis: Stabilizers and Silencers https://pubmed.ncbi.nlm.nih.gov/42099466/

Tafamidis Treatment for Patients With Transthyretin Amyloid Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/30145929/

Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/38197816/

Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/39213194/

Diagnostic and Prognostic Value of 99mTc-Pyrophosphate SPECT/CT in Patients With Transthyretin Amyloid Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/42135510/

Immunoglobulin-Related Amyloidosis https://emedicine.medscape.com/article/208839-overview

Brain-Type Natriuretic Peptide (BNP) https://emedicine.medscape.com/article/2087425-overview

The Finkelstein-Schoenfeld Test: A Note on Some Overlooked Issues Concerning Power https://pubmed.ncbi.nlm.nih.gov/38316728/

The Win Ratio in Cardiology Trials: Lessons Learnt, New Developments, and Wise Future Use https://pubmed.ncbi.nlm.nih.gov/39405050/

Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance https://pubmed.ncbi.nlm.nih.gov/41171219/

Disentangling Knots of Misfolded Proteins: Do We Really Know the Prognostic Implications of the Pathogenic V122I TTR Variant https://pubmed.ncbi.nlm.nih.gov/38657853/

Detecting Polyneuropathy in Patients With Hereditary Transthyretin Amyloid Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/41732581/

Futility Monitoring in Clinical Trials https://pubmed.ncbi.nlm.nih.gov/40497544/

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) https://clinicaltrials.gov/study/NCT04136171

Transthyretin Cardiac Amyloidosis: Current and Emerging Therapies https://pubmed.ncbi.nlm.nih.gov/39841315/

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