Super-resolution microscopy reveals the secret of neuronal architecture | Dr. Christophe Leterrier

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 In this episode, we speak with Christophe Letterrier, PhD, the leader of the NeuroCyto research group at the Institute of Neurophysiopathology, Aix-Marseille University. We dive deep inside neurons, discussing the structural support and trafficking system in the cells - the cytoskeleton. Visualising molecules comprising this structure requires super-resolution microscopy, hence, we explore cutting-edge techniques from the world of imaging. Dr. Leterrier emphasises the importance of the community and open science principles in research and tool development. Finally, we address challenges in the publishing system and the mindset required for an academic career. Our channel is supported by International Max Planck Research School (IMPRS) for Neurosciences as well as Cluster of Excellence Multiscale Bioimaging (MBExC) in Göttingen, Germany. The views presented on this channel are not representative of IMPRS or MBExC. 

 Timestamps: 
00:00:00 Intro 
00:03:00 Early career and motivation for doing science 
00:09:17 Establishing own research group in Marseille, France 
00:11:47 Cell architecture, trafficking, cytoskeleton and the molecules involved 00:17:54 Origin of action potentials - electric pulses in the neurons. 
00:21:23 Relevance of basic research 
00:24:25 Neuronal cultures: studying neurons in a dish 
00:29:42 Super-resolution microscopy 
00:34:27 Single molecule localisation microscopy: STORM, SIM and imaging living cells 00:45:57 Open science algorithms for image analysis (SRRF) 
00:51:19 Combining different techniques: platinum replica electron microscopy and STORM 
00:55:39 Social media as a way of fostering scientific community
01:02:47 Failures in academia
01:07:07 Problems in academia: publishing and reviewing system 

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Neuroscience and Beyond team:
 Svilen Georgiev 
Kristina Jevdokimenko 
Sabina Nowakowska 

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