First reactions | Shimon Sakaguchi, Nobel Prize in Physiology or Medicine 2025 | Telephone interview

"I believe this will encourage immunologists and physicians to apply the T regulatory cells to treat various immunological diseases.” Shimon Sakaguchi, 2025 Nobel Prize laureate in physiology or medicine, has always been driven by the desire to find new ways to combat disease. In this conversation with the Nobel Prize’s Adam Smith, recorded just after the prize announcement, Sakaguchi speaks briefly about his surprise at the news and reflects on the fundamental research question that kept him dedicated to the field after many others abandoned it, a question that took over two decades to answer.

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