004-Neuroinflammation Across Neurological Diseases

This is an excerpt from a review article titled "The Role of Neuroinflammation in Neurological Diseases," co-authored by Fu Dongshi and V. Wee Yong, published in Science magazine. The article explores the role of neuroinflammation in various neurological diseases (such as multiple sclerosis, stroke, Alzheimer's disease, and Parkinson's disease). It elaborates in detail on how immune cell infiltration and activation of central nervous system-resident microglia and astrocytes constitute neuroinflammation, and points out that this inflammation both serves a protective function and is often accompanied by damage during disease progression. The article also compares the commonalities and differences of neuroinflammation across different diseases, and looks ahead to therapeutic strategies targeting neuroinflammation, particularly emphasizing the potential of drug development targeting inflammation within the central nervous system.

References:

• Shi F D, Yong V W. Neuroinflammation across neurological diseases[J]. Science, 2025, 388(6753): eadx0043.