025-The Neuroimmune Connectome in Health and Disease

This review article explores the neuroimmune connectome, defining it as the comprehensive network of interactions between the nervous and immune systems throughout the body. The authors summarize advancements in understanding neuroimmune communication, particularly within the central nervous system (CNS), examining how the CNS responds to immune signals and the immunological effects of CNS activity. The text highlights these interactions in the context of neurological diseases, the regulation of immunity, and the control of complex behaviors, including neurodegeneration and sickness behaviors. Finally, it discusses the impact of environmental factors and emerging technological tools used to investigate these intricate neuroimmune pathways.

References:

• Wheeler, M.A., Quintana, F.J. The neuroimmune connectome in health and disease. Nature 638, 333–342 (2025). doi.org