1088-Interferon-inflammaging links epigenetic age

This research examines the critical link between chronic inflammation and accelerated biological aging. By analyzing four diverse groups of people, scientists discovered that inflammatory proteins related to the interferon pathway do not just correlate with aging but actually serve as causal drivers of epigenetic age acceleration. The findings highlight that epigenetic clocks focused on health span, such as GrimAge and PhenoAge, are superior at predicting multimorbidity and frailty compared to traditional lifespan-based measures. Ultimately, the authors propose that targeting these specific immune signals could provide a viable pathway for developing new anti-aging therapies to improve long-term health.

References:

• Liu Z, Ziogas A, Zhang Y, et al. Interferon-related inflammaging links epigenetic age acceleration to multimorbidity[J]. Cell Genomics, 2026.