1115-SPART: Regulator of Orthoflavivirus Uncoating

Researchers have identified a host protein called SPART that functions as a broad restriction factor against orthoflaviviruses, including Zika and Dengue. Using a CRISPR activation screen, the study discovered that SPART inhibits viral infection by sequestering another host protein, ITCH, and preventing its normal localization. Under typical conditions, ITCH facilitates the ubiquitination and degr...去小宇宙查看完整单集简介
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