1127-Dual Targeting Mechanisms of Tetracyclines

Researchers have identified a dual-site mechanism of action for the tetracycline class of antibiotics, revealing that these drugs target both the mRNA decoding center and the nascent peptide exit tunnel (NPET) of the bacterial ribosome. Using high-resolution cryo-electron microscopy, the study demonstrates that while tetracyclines traditionally disrupt translation at the 30S subunit, they also bin...去小宇宙查看完整单集简介
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