1149-Chromatin Remodeling in Cancer Dedifferentiation

This study investigates how melanoma cells escape treatment by transitioning into drug-tolerant persister states through a process of reversible dedifferentiation. By analyzing multi-omics data, the researchers identified that this transition is driven by two sequential transcriptional waves that orchestrate a global reconfiguration of the chromatin landscape. The first wave is triggered by oxidat...去小宇宙查看完整单集简介
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