Antibody-drug Conjugate Design and Function for Cancer Treatment

In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Sophia N. Karagiannis (King’s College London) about the recently published Review article by Cheung et al. The authors review the latest research into antibody-drug conjugates (ADCs), referred to as “magic bullets” that kill cancer cells with minimal damage to healthy tissue. What are the main obstacles to manufacturing ADCs and can they be used to treat all types of cancer? Listen now to find out.

Anthony Cheung, Yi Liu, Alicia M. Chenoweth, Hanieh Montaseri, Benjamina Esapa, Vijay Chudasama, James R. Baker, David E. Thurston, and Sophia N. Karagiannis Antibody-drug conjugate design and mechanisms of action for cancer treatment: state of the art and beyond Physiological Reviews, published April 20, 2026. DOI: 10.1152/ physrev.00039.2025