Decoding Aging and the Environment with Cornelia van Duijn

Welcome to the Olink® Proteomics in Proximity podcast! 

Below are some useful resources mentioned in this episode: 

Olink tools and software

Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

Research articles

The support of human genetic evidence for approved drug indications

Matthew R Nelson et al,  Nature Genetics 2015

https://www.nature.com/articles/ng.3314

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

M. Austin Argentieri et al,  Nature Medicine 2024

https://www.nature.com/articles/s41591-024-03164-7

Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

Ludger J.E. Goeminne et al, Cell Metabolism 2024, in press

https://www.sciencedirect.com/science/article/abs/pii/S1550413124004017?via%3Dihub

Plasma proteomic associations with genetics and health in the UK Biobank

Benjamin B. Sun et, Nature 2023

https://www.nature.com/articles/s41586-023-06592-6

Rare variant associations with plasma protein levels in the UK Biobank

Ryan S. Dhindsa; Nature 2023

https://www.nature.com/articles/s41586-023-06547-x

Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank

Manik Garg, Nature Genetics, 2024

https://www.nature.com/articles/s41588-024-01898-1

China Kadoorie Biobank: https://www.ckbiobank.org/publications

Publications: https://www.ckbiobank.org/publications

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