[7] UNA BIOTECNÓLOGA ENTRE FÍSICOS #ClaraVilches

TEMAS - Comunicación entre biólogos y físicos - Réplicas experimentales en biología, no tan necesarias en física o matemáticas - Excel vs Matlab - Reciclar plásticos en centros de investigación - Programas del ICFO: Light for health, life for energy and life for information - Terapia plasmónica fototérmica: matar células de cáncer con nanopartículas de oro, luz y calor. - Primera nanomedicina aprobada para el cáncer: doxil (doxorubicina acoplada a lisosomas). - Abraxane (paclitaxel): fármaco quimioterapéutico basado en nanopartículas - Aumento de la permeabilización en células cancerosas - El sistema educativo en Finlandia - El carácter finlandés - Hablar aranés - Doctores senior que no quieren o no pueden ser jefes de grupo - Carreras de chicas y carreras de chicos - Desbalance entre mujeres y hombres entre líderes de grupo NOTAS Y ENLACES: -Fundación plástico precioso (Fundacio plastic precios): https://plasticprecioslasafor.org/ -Sustainable Research Barcelona: https://bist.eu/sustainable-research/ https://ibecbarcelona.eu/about-us/sustainable-research/ -Nanomedicina doxil contra el cáncer: https://es.oncolink.org/tratamiento-del-cancer/oncolink-rx/doxorubicin-liposomal-doxil-r https://www.elsevier.es/es-revista-educacion-quimica-78-articulo-la-nanomedicina-sistemas-liberacion-farmacos-S0187893X16300295 CLARA VILCHES EN YOUTUBE. Terapia plasmónica fototérmica de cáncer con nanopartículas de oro: https://youtu.be/wko93JCYwKk Terapia fototérmica contra el cáncer: https://es.wikipedia.org/wiki/Terapia_fotot%C3%A9rmica Las "mamás" de la fototerapia: Naomi Halas y Jennifer West https://halas.rice.edu/halas-bio https://bme.duke.edu/faculty/jennifer-west Idioma Aranés: https://es.wikipedia.org/wiki/Aran%C3%A9s El aranés es la lengua materna de 2.785 personas. GLOSARIO: Apoptosis: Muerte celular de una manera programada, que requiere uso de energía y un programa genético y proteico. Necrosis: Muerte celular de un modo pasivo en el que la célula pierde su actividad metabólica. LOCALIZACIÓN: Castelldefels https://www.icfo.eu/ ‍ SOBRE CLARA VILCHES: https://www.icfo.eu/about-icfo/people/directory/?id=1069 CV: WORK EXPERIENCE EDUCATION AND TRAINING April 2018 – Present Postdoctoral researcher Institut de Ciències Fotòniques ICFO – Castelldefels (Barcelona) Principal Investigator: Dr Romain Quidant – Nanophotonics research area, and Dr Turgut Durduran – Biophotonics research area. March 2015 – March 2018 Research engineer Institut de Ciències Fotòniques ICFO – Castelldefels (Barcelona) Principal Investigator: Dr Romain Quidant. Nanophotonics research area. September 2009 – July 2010 Research technician Institut d’Investigació Biomèdica de Bellvitge (IDIBELL) – Barcelona Principal Investigator: Dra Virginia Nunes. Human Molecular Genetics Area – Group of Molecular basis of inherited diseases (cystinuria, lysinuric protein intolerance, Wolfram Syndrome and megalencephalic leukoencephalopathy with subcorticals cysts) and mithocondrial genetics. August 2010 – November 2015 PhD in Biomedicine Universitat de Barcelona (UB) – Institut d’Investigació Biomèdica de Bellvitge (IDIBELL) ▪ Thesis title: “Molecular basis of amino acid transport in kidney and skeletal muscle: Lessons from knockout mouse models”, directed by Dra Virginia Nunes and co-directed by Dr Manuel Palacín. Thesis developed mainly at Institut d’Investigació Biomèdica de Bellvitge with collaborations at Parc Científic de Barcelona. Defense date: 08/01/2016 September 2010 – July 2011 Master Degree in Biomedicine Universitat de Barcelona (UB) ▪ Master thesis project: “Amino acid transporters gene expression in skeletal muscle of LAT2 KO mice”, directed by Dra Virginia Nunes at Institut d’Investigació Biomèdica de Bellvitge (IDIBELL – Barcelona). December 2009 Accreditation as Researcher in animal experimentation Animal Experimentation Service – Universitat de Barcelona (UB) September 2003 – July 2009 Degree in Biotechnology Universitat Autònoma de Barcelona (UAB) Curriculum Vitae Clara Vilches Caubet February 2008 – July 2008: Participation in the Project “ADOPT. Controlling the quality of biogas”, developed by the Biotechnology and Environmental Microbiology research group at Hämeen Amattikorkeakoulu – University of Applied Sciences of Hämeenlinna, Finland, directed by Tuija Pirttijärvi under the Erasmus European Program. ▪ March 2009 – July 2009: Final Project: “Role of RnaseL in mithocondrial genic regulation in prostate cancer”, directed by Dra Virginia Nunes at Institut d’Investigació Biomèdica de Bellvitge (IDIBELL – Barcelona). PUBLICACIONES RECIENTES: Article Influence of cell type on the efficacy of plasmonic photothermal therapy Villuendas H, Vilches C*, Quidant R* ACS Nanoscience Au, 2022 *co-corresponding authors Article Treatment of hepatic fibrosis in mice based on targeted plasmonic hyperthermia Ribera J, Vilches C, Sanz V, de Miguel I, Portolés I, Córdoba-Jover B, Prat E, Nunes V, Jiménez W, Quidant R, Morales-Ruiz M ACS Nano, 2021 Book Chapter Targeted hyperthermia with plasmonic nanoparticles Vilches C and Quidant R. In Frontiers of Nanoscience, Elsevier Ltd, 2020 Article Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy Morales-Dalmau J, Vilches C, Sanz V, de Miguel I, Rodríguez-Fajardo V, Berto P, Martínez-Lozano M, Casanovas O, Durduran T, Quidant R. Nanoscale, 2019 Article Dysfunctional LAT2 amino acid transporter is associated with cataract in mouse and humans Boiadjieva Knöpfel E*, Vilches C*, Camargo S, Errasti-Murugarren E, Stäubli A, Mayayo C, Munier FL, Miroshnikova N, Poncet N, Junza A, Bhattacharya S, Prat E, Berry V, Berger W, Heon E, Moore AT, Yanes O, Nunes V, Palacín M, Verrey F, Kloeckener-Gruissem B. Frontiers in Physiology, section Renal and Epithelial Physiology, 2019 * co-author Article Non-invasive and quantitative in vivo monitoring of gold nanoparticle concentration and tissue hemodynamics by diffuse optical spectroscopy Mireles M, Morales-Dalmau J, Johansson JD, Vidal-Rosas E, Vilches C, Martínez-Lozano M, Sanz V, de Miguel I, Casanovas O, Quidant R, Durduran T. Nanoscale, 2019 Article Cooperation of antiporter LAT2/CD98hc with uniporter TAT1 for renal reabsorption of neutral amino acids Vilches C*, Boiadjieva-Knöpfel E*, Bodoy S, Camargo S, López de Heredia M, Prat E, Ormazabal A, Artuch R, Zorzano A, Verrey F, Nunes V, Palacín M. Journal of the American Society of Nephrology JASN, 2018 * co-author Article Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in AgeRelated Hearing Loss Espino M, Font-Llitjós M. Murillo-Cuesta S, Errasti-Murugarren, Celaya A, Girotto G, Vuckovic D, Mezzavilla M, Vilches C, Bodoy S, Sahún I, González L, Prat E, Zorzano A, Dierssen M, Varela-Nieto I, Gasparini P, Palacín M, Nunes V. eLife, 2018 Article Optimum morphology of gold nanorods for light-induced hyperthermia Morales-Dalmau J, Vilches C, de Miguel I, Sanz V, Quidant R. Nanoscale, 2017 Article In vivo testing of gold nanoparticles using the Caenorhabditis elegans model organism González-Moragas L, Berto P, Vilches C, Quidant R, Kolovou A, Santarella-Mellwig R, Schwab Y, Stürzenbaum S, Roig A, Laromaine A. Acta Biomaterialia, 2017 Article Digenic inheritance in cystinuria mouse model Espino M, Font-Llitjós M, Vilches C, Salido E, Prat E, López de Heredia M, Palacín M, Nunes V. PLoS One, 2015 Article Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. Hoegg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson M, Gödde K, Vilches C, de Heredia ML, Nunes V, Estévez R, Jentsch TJ. Nature Communications, 2014