Chronic Lymphocytic Leukemia — An Interview with Dr Catherine C Coombs on Real-World Cases and Current Questions and Controversies Presented at Recent Conferences

Featuring an interview with Dr Catherine C Coombs, including the following topics:

• Case: A woman in her early 80s with dementia and newly diagnosed IGHV-mutated del(13q) chronic lymphocytic leukemia (CLL) receives initial treatment with zanubrutinib (0:00)
• Current and investigational initial therapy approaches for CLL (13:41)
• Case: A man in his late 40s under observation for asymptomatic CLL develops worsening symptoms and initiates treatment with venetoclax/obinutuzumab (28:15)
• Phase III AMPLIFY trial of fixed-duration acalabrutinib combined with venetoclax with or without obinutuzumab as first-line treatment for CLL (36:02)
• Other novel venetoclax combinations for the treatment of CLL (43:36)
• Case: A man in his mid 70s with multiregimen-refractory CLL receives pirtobrutinib (46:51)
• Personal perspectives on the activity and tolerability of pirtobrutinib; sequencing pirtobrutinib and chimeric antigen receptor T-cell therapy for patients with CLL (51:16)

CME information and select publications