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Research To Practice | Oncology Videos

HR-Positive Metastatic Breast Cancer — An Interview with Dr Seth Wander on Biomarker Assessment and Related Treatment Decision-Making (Companion Faculty Lecture)

38 min16 april 2026

Featuring a slide presentation and related discussion from Dr Seth Wander, including the following topics:

  • Biological impact of clinically relevant biomarkers (eg, ESR1 mutations, PIK3CA/AKT1/PTEN alterations) (0:00)
  • Methodologies for biomarker assessment in clinical practice: Tissue versus liquid biopsy (5:21)
  • Methodologies for biomarker assessment in clinical practice: Novel platforms (13:56)
  • Appropriate timing for assessment of ESR1 and PI3K pathway alterations (17:34)
  • Evolving guidelines for routine biomarker evaluation (21:37)
  • Implications of precision oncology clinical trials for future biomarker utility (25:07)
  • Summary, key questions, future directions (33:09)

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