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Research To Practice | Oncology Videos

Myelofibrosis — An Interview with Dr Raajit K Rampal on Key Presentations from the 66th American Society of Hematology (ASH) Annual Meeting

43 min16 april 2025

Featuring an interview with Dr Raajit K Rampal, including the following topics:

  • Clinical decision-making in the initiation and stopping of systemic therapy for myelofibrosis (MF) (0:00)
  • Novel research strategies involving CDK4/6 inhibitors for MF (8:03)
  • Implications of the JUMP study for clinical practice (10:00)
  • Therapeutic switching strategies with JAK inhibitors for MF (12:17)
  • Clinical rationale for the use of luspatercept and elritercept for MF (15:35)
  • Emerging clinical data involving BET inhibitors for MF (16:57)
  • Tolerability concerns with selinexor in patients with MF (20:01)
  • Mechanism of and clinical data with the MDM2 inhibitor navtemadlin for MF (22:32)
  • Additional novel strategies under clinical investigation for MF (25:52)
  • Potential transformation of myeloproliferative neoplasms to acute myeloid leukemia (29:40)
  • Management of polycythemia vera and essential thrombocythemia (34:27)
  • General management principles for myeloproliferative neoplasms (37:53)

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