Myelofibrosis | Oncology Today with Dr Neil Love: Current Management of Myelofibrosis

Featuring an interview with Dr Brady Stein, including the following topics:

• Case: A man in his late 70s with myelofibrosis (MF) presenting with fatigue and night sweats (0:00)
• Incidence and severity of fatigue and other symptoms; use of symptom scales to measure severity (3:43)
• Rapidity of symptom response to ruxolitinib; emerging data with momelotinib (7:34)
• Novel therapeutic targets for MF: BET, PI3K and BCL2 (13:25)
• Available data on JAK inhibitors for essential thrombocytosis and polycythemia vera; pathogenesis of pruritus and optimal management (20:31)
• Clinical pearls on managing splenomegaly, weight loss and other MF symptoms (26:34)
• Risks of localized therapy for splenomegaly; splenic progression among patients receiving ruxolitinib (30:14)
• Prevention and management of withdrawal rebound from ruxolitinib; factors to consider in choosing JAK inhibitors for different risk groups (34:17)
• Myths and misperceptions about MF among community general oncologists (38:26)
• Management algorithms for transplant-eligible and transplant-ineligible patients (44:32)
• Current understanding of MF pathophysiology; end-of-life care for patients with MF (50:13)

CME information and select publications