Episode 39: Undifferentiated Pleomorphic Sarcomas

Undifferentiated Pleomorphic Sarcomas are one of the most common sarcomas. This class of tumors are aggressive with a risk of local recurrence and distant metastasis. We discuss the presentation, diagnostic challenges, and management of these sarcomas. Bennett C, Bharadwaj S, Arndt A, Chawla A. A systematic review of undifferentiated pleomorphic sarcoma of the chest wall. Chin Clin Oncol. 2023 Dec;12(6):66. Lesovaya EA, Fetisov TI, Bokhyan BY, Senchenko MA, Rogozhin DV, Maksimova VP, Demko AN, Belitsky GA, Yakubovskaya MG, Kirsanov KI. Genetic Heterogeneity of Undifferentiated Pleomorphic Sarcoma: Is There Potential for Targeted Therapy? Cancers (Basel). 2025 Nov 10;17(22):3613 Sun H, Liu J, Hu F, Xu M, Leng A, Jiang F, Chen K. Current research and management of undifferentiated pleomorphic sarcoma/myofibrosarcoma. Front Genet. 2023 Feb 16;14:1109491 xFind out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/