Sugar Monoesters as Absorption Enhancers for Orally-Delivered Large Pharmaceuticals - Professor David J. Brayden, University College Dublin

The lining of the gut acts naturally as a protective barrier to harmful or oversized materials. Many  orally-administered drugs consisting of macromolecules or peptides are difficult to deliver because of  their poor permeability across the intestine resulting in failure to reach the bloodstream. Patient  preference would be to take these types of medicines orally rather than the currently available  delivery route of injections. Professor David J. Brayden, at University College Dublin, is dedicated to  enhancing the oral delivery of peptides and other macromolecules. His team and collaborators are  conducting cutting edge research on the effects of specific sugar-based monoesters as intestinal  permeation enhancers.