Ep. 4 From Screens to SLCs: What Makes a Good Assay Great

In this episode of The BioDisruptors Podcast, we dive into the art and science of assay development; a critical, yet often overlooked, part of the drug discovery pipeline. 

We explore Solute Carriers (SLCs), what makes a “good” assay and how thoughtful assay design drives reliable, reproducible results in biopharma research. Along the way, we discuss insights from the Assay Guidance Manual, a gold-standard resourced developed by NCATS and Eli Lilly, and break down findings from a recent Frontier in Pharmacology titled “Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.”

Whether you’re new to assay development or just want a refresher on best practices, this episode delivers practical insights with real-world relevance. 

Featured Publications: Advancing Drug Discovery Through Assay Development: A Survey of Tool Compounds within the Human Solute Carrier Superfamily (https://doi.org/10.3389/fphar.2024.1401599)

Assay Guidance Manual (https://www.ncbi.nlm.nih.gov/books/NBK53196/)