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The Curbsiders Internal Medicine Podcast

#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

1 tim 6 min16 mars 2026

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior.  Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Alex Chaitoff (@alexchaitoff), Nora Taranto (@norataranto), & Matt Watto (@doctorwatto).

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Credits

  • Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP
  • Cover Art: Nora Taranto MD, MSCE
  • Reviewer: Sai S Achi MD, MBA, FACP
  • Technical Production: Pod Paste
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP


Show Segments

  • Intro, disclaimer
  • GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT 
  • Weight Regain after Weight loss 
  • VALAD – Valacyclovir in patients with early Alzheimer’s 
  • Nudges to increase Deprescribing 
  • Outro


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