Start / The Dissenter / 857 amy arnsten the prefrontal cortex and how it responds to stress

#857 Amy Arnsten: The Prefrontal Cortex, and How It Responds to Stress

72 min • 6 november 2023

------------------Support the channel------------

Patreon: https://www.patreon.com/thedissenter

PayPal: paypal.me/thedissenter

PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l

PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz

PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m

This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/

Dr. Amy Arnsten is Albert E. Kent Professor of Neuroscience and Professor of Psychology, and member of the Kavli Institute of Neuroscience at Yale University. Dr. Arnsten is an international expert on the molecular regulation of higher cortical circuits, and a member of the National Academy of Medicine. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease.

In this episode, we talk about the prefrontal cortex and the role it plays in neurological and mental disorders. We start by talking about the organization and functional properties of the prefrontal cortex. We discuss ADHD, conduct disorder, and the neurological effects of long-COVID. We get into the biochemical mechanisms behind stress responses. We talk about PTSD, and how to treat it. We talk about the neurological effects of chronic stress. We discuss why the prefrontal cortex is so vulnerable to stress. We talk about targeting aging itself and the mechanisms of aging to prevent neural disorders. Finally, we discuss how neuroscience can help us become more compassionate.

A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, OLAF ALEX, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, MIKKEL STORMYR, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, DANIEL FRIEDMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ANTON ERIKSSON, CHARLES MOREY, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, STARRY, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, CHRIS STORY, KIMBERLY JOHNSON, BENJAMIN GELBART, JESSICA NOWICKI, LINDA BRANDIN, NIKLAS CARLSSON, ISMAËL BENSLIMANE, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, KATE VON GOELER, ALEXANDER HUBBARD, LIAM DUNAWAY, BR, MASOUD ALIMOHAMMADI, PURPENDICULAR, JONAS HERTNER, URSULA GOODENOUGH, GREGORY HASTINGS, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, ERIK ENGMAN, AND LUCY!

A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, AL NICK ORTIZ, AND NICK GOLDEN!

AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, BOGDAN KANIVETS, AND ROSEY!

Senaste avsnitt

#1134 Norbert Peeters: Botanic Philosophy, von Humboldt, Darwin, and Why Plants Matter

8 augusti | 98 min

#1133 Blake Roeber - Political Humility: The Limits of Knowledge in Our Partisan Political Climate

7 augusti | 61 min

#1132 Kevin Mitchell: Free Will, Robert Sapolsky, the Genomic Code, and Human Embryo Editing

4 augusti | 129 min

7 Years and 1/2: Fundraising Campaign

2 augusti | 2 min

#1131 Alan Love: How Can Development Influence Evolution?

1 augusti | 58 min

#857 Amy Arnsten: The Prefrontal Cortex, and How It Responds to Stress

Senaste avsnitt

#1134 Norbert Peeters: Botanic Philosophy, von Humboldt, Darwin, and Why Plants Matter

#1133 Blake Roeber - Political Humility: The Limits of Knowledge in Our Partisan Political Climate

#1132 Kevin Mitchell: Free Will, Robert Sapolsky, the Genomic Code, and Human Embryo Editing

7 Years and 1/2: Fundraising Campaign

#1131 Alan Love: How Can Development Influence Evolution?

#1130 Sam Carr: How People Deal With Loneliness

#1129 Agnes Callard - Open Socrates: The Case for a Philosophical Life

#1128 Daniel Silverman: Why People Believe Misinformation in War

#1127 Jonathan Losos - Improbable Destinies: Fate, Chance, and the Future of Evolution

#1126 Nicole Prause: Pornography, NoFap, and Orgasm

#1125 Daniel Fessler: Physical Formidability, Male Muscularity, Pathogen-Avoidance & More

#1124 Miguel Segundo Ortín & Vicente Raja: Ecological Psychology

#1123 Philip Nitschke: Assisted Suicide and the Right to Die

#1122 Daniela Rodrigues: Communication in Apes and Humans, and the Cognitive Foundations of Language

#1121 Deena Emera: A Brief History of the Female Body

#1120 Pascal Boyer: Ritualized Behavior, Ownership Psychology, and Victim-Devaluation

#1119 Anna Ivanova: Language and Large Language Models

#1118 Peter Adamson - Heirs of Avicenna: Philosophy in the Islamic East, 12-13th Centuries

#1117 Stephen Morris - Moral Damages: The Case for Abolishing Morality

#1116 Adam Safron: Consciousness, AI, Psychedelics, and The Self

#1115 Patrícia Silva: Portugal in the 21st Century

#1114 Sybil Hart: Attachment and Parent-Offspring Conflict

#1113 Vicky Oelze: The Diets of Great Apes, and the Evolution of Human Diets

#1112 Angela Potochnik - Recipes for Science: An Introduction to Scientific Methods and Reasoning

#1111 Charlotte Blease - The Nocebo Effect: When Words Make You Sick

#1110 Willem Frankenhuis: Human Development in Harsh and Unpredictable Environments

#1109 Stefanos Geroulanos: The Invention of Prehistory

#1143 Brian Lerch: Same-Sex Sexual Behavior, Indiscriminate Sexual Behavior, Attachment, and Divorce

#1108 Laurie Mintz - Becoming Cliterate: Why Orgasm Equality Matters and How to Get It

#1107 Donald Johanson: Lucy, Australopithecus afarensis, and Homo habilis

#1106 Kevin Hong: Magic, Divination, and Dream Interpretation Across Societies

#1105 Kostas Kampourakis - Trusting Science: Why We Need to Reconsider School Science Teaching

#1104 Vanessa Wills: Marx's Ethical Vision

#1103 Paul Seabright - The Divine Economy: How Religions Compete for Wealth, Power, and People

#1102 Mandi Astola: Character, Virtue, and Vice

#1101 Laura Betzig - The Badge of Lost Innocence: A History of the West

#1100 Jonathan Ichikawa: Epistemic Courage

#1099 Manvir Singh - Shamanism: The Timeless Religion

#1098 Karen Stollznow - B*tch: The Journey of a Word

#1097 Kostas Kampourakis: Debunking Myths and Falsehoods About Charles Darwin

#1096 Cahal Moran (Unlearning Economics): Why We’re Getting Poorer

#1095 Robert Krueger: Classification of Mental Disorders, and Mental Wellbeing

#1094 Cody Moser: Collective Intelligence and Cultural Innovation

#1093 Agustín Fuentes - Sex Is a Spectrum: The Biological Limits of the Binary

#1092 Mads Larsen: Mating Ideologies, Dating Dysfunction, and Demographic Collapse

#1091 Vlasta Sikimić: Cognitive Diversity in Science, and the Ethics of AI

#1090 Daniel Conroy-Beam: How the Manosphere Misuses Evolutionary Psychology

#1089 Alexander Thomas: The Politics and Ethics of Transhumanism

#1088 Karoline Wiesner: What Is a Complex System?

#1087 Susie Gronski: Men's Sexual Health

#1086 John Odling-Smee - Niche Construction: How Life Contributes to Its Own Evolution

#1085 Joshua Glasgow - The Significance Impulse: On the Unimportance of Our Cosmic Unimportance

#1084 Patrick Hassan: The Pilosophy of Suicide

#1083 Matt Grossmann: How the Diploma Divide and the Culture War Transformed American Politics

#1082 Wade Allison: Misconceptions About Nuclear Energy

#1081 Richard Wolff: Trump's Tariffs, Elon Musk, and the BRICS

#1080 Tristan Rogers: Conservatism, Past and Present

#1079 Christopher Federico: Political Preferences, Belief Systems, Collective Narcissism, & More

#1078 Debra Lieberman: The Evolutionary Psychology of Disgust, Gratitude, and Emotional Tears

#1077 Blaine Fowers: The Science of Virtue

#1076 Elisabeth Bik: Scientific Integrity and Scientific Fraud

#1075 Michael Cook: A History of the Muslim World (Part 1)

#1074 Kevin Lala - Evolution Evolving: The Developmental Origins of Adaptation and Biodiversity

#1073 David Wolpert: History as a Stochastic Process

#1072 Steven Heine: How Existential Psychology Can Help Us Build Meaningful Lives in Absurd Times

#1071 Marina García-Granero: Nietzsche, the Genealogical Method, the Death of God, and Nihilism

#1070 Cláudia Passos Ferreira: The Development of Consciousness and Morality

#1069 Todd May: Should We Go Extinct?

#1068 Kristen Ghodsee: Why Women Have Better Sex Under Socialism

#1067 David Benatar - Very Practical Ethics: Engaging Everyday Moral Questions

#1066 Karl Friston: The Free Energy Principle, Culture, 4E Cognition, and Physics

#1065 Daniel Williams: Is the Science of Misinformation Reliable?

#1064 Costica Bradatan - In Praise of Failure: Four Lessons in Humility

#1063 Menelaos Apostolou: The Evolution of Singlehood

#1062 Nandita Bajaj: We Have an Overpopulation Problem

#1061 Lauren Ross: Causation and Explanation in Science

#1060 João Cancela: Atitudes Políticas, Confiança nas Instituições e Populismo em Portugal

#1059 Christopher Hoyt: Wittgenstein, Philosophy of Mind, and Religion