Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows

In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture.

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⏱ Chapters

0:00 – Cold open & intro

1:08 – Cancer metabolism overview

2:24 – Glucose-ketone index explained

5:01 – Lean mass hypersponders & glucose

9:18 – Acetone measurement & respiration

13:49 – Insulin, ketones & cancer signaling

19:05 – Growth factors & VEGF discussion

25:29 – Stomach acidity & nutrient absorption

32:08 – How cancer cells originate

35:43 – Cardiolipin, melatonin & apoptosis

43:05 – Diet quality & food as function

52:14 – Chemotherapy & metabolic protocols

1:03:36 – Patient outcomes & biopsy risks

1:14:32 – IV vitamin C trial findings

1:22:07 – Ideal cancer metabolism trial design

1:29:36 – Sunlight, melanin & mitochondria

1:37:20 – Osteocyte biology & osteocalcin

1:46:43 – Research culture & scientific rigor

1:54:36 – Most underappreciated biomarker

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