EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens

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In this episode, we welcome Jake Rubens, a seasoned genomic science entrepreneur and co-founder of Quotient Therapeutics. Tune in to hear Jake discuss the potential of somatic genomics (genes that are present in any cell in the body except for germline cells) in therapeutic development. As the founder of several companies, including Tessera and Sana Therapeutics, Jake offers his unique perspective on the advantages of utilising insights from somatic genome sequencing to understand disease mechanisms and discover new drug targets. He also shares valuable lessons from his robust entrepreneurial journey!

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EP 256: Cutting through the AI hype in drug discovery with Dave Hallett of Recursion

EP 255: Turning long-read sequencing into a routine part of clinical care with Danny Miller of the University of Washington

EP 254: Triangulating genetic evidence and dodging bias to pick winning drug targets with Brent Richards of 5 Prime Sciences

EP 253: The genetics of brain size, growth, and aging with Andrew Jackson of the University of Edinburgh

EP 252: The diagnosis that became a mission to cure rare disease: Advancing genetic medicine using AI with Stevie Ringel of Nome

EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio

EP 250: Redefining rare disease realities with Sharon Terry of the Genetic Alliance [Re-run]

EP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl Anderson of the Wellcome Sanger Institute

EP 248: The blood mutations rewriting cardiovascular risk: Clonal hematopoiesis and polygenic risk with Pradeep Natarajan of Massachusetts General Hospital