Discovering Ketamine with Dr. Edward Domino

In this episode I sit down the arylcyclohexylamine legend Dr. Edward F. Domino to discuss his pioneering research on ketamine, his subsequent research on NMDA antagonists, and his first encounter with a patient who reported antidepressant activity from using ketamine.
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0:00 Introduction & context
2:45 The discovery of ketamine
8:30 Phencyclidine derivatives & Parke-Davis
14:15 First human administration of ketamine
19:30 The testicle compression experiment
23:45 Initial impressions & anesthetic potential
28:15 Collaboration with psychiatrists at Lafayette Clinic
32:00 Ketamine as a model for schizophrenia
36:30 The missed antidepressant discovery
42:15 The patient who knew better
46:45 Regret & listening to patients
51:00 FDA approval & antidepressant recognition
55:30 John C. Lilly & Marsha Moore
59:00 R-ketamine vs S-ketamine
63:45 The right-hand form & less dissociation
68:30 The Cal Stevens patent scandal
74:00 Cal Stevens the medicinal chemist
79:00 A missed opportunity to meet Cal Stevens
83:15 The endogenous ligand question
87:45 Complex mechanisms of ketamine action
92:00 Sigma receptors & research opportunities
96:30 R-ketamine as the future direction
101:00 Career advice & getting funded
105:30 The importance of permission from your boss
109:15 LSD-25 & other opportunities
112:45 Final reflections on legacy & family

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