Ep. 107: “Immune Cell Manipulation” Featuring Dr. Rizwan Romee

Guest:

Dr. Rizwan Romee is a Oncologist at the Dana-Farber Cancer Institute and Associate Professor at Harvard Medical School, where his research focuses on genetically manipulating NK cells to enhance their anti-tumor function. He talks about advances and challenges in engineering NK cells for cancer therapy. He also discusses using E. coli to deliver immune-activating cytokines to tumors. (37:31)

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The Immunology Science Round Up

The Y Chromosome in Cancer – Loss of the Y chromosome in tumor and T cells worsens survival. (5:00)

Boosting CD8 T Cell Responses – Cytokine-adjuvanted mRNA-lipid nanoparticles can enhance immune response to vaccination. (11:40)

Bacterial Antitumor Immunotherapy – Intratumoral Listeria monocytogenes can either enhance or inhibit tumor progression. (21:30)

NK Cell Signaling – CAR activation and IL-15 signaling rapidly induce CREM upregulation in NK cells. (28:20)