Ep. 115: “Intercellular Communication” Featuring Dr. Harikesh Wong

Guest:

Dr. Harikesh Wong is an Assistant Professor at the Ragon Institute and MIT, where his lab studies the design principles of the immune system.  He talks about how Tregs constrain conventional T cell responses during infection, and advanced fluorescence microscopy techniques to study immune responses. (38:11)

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The Immunology Science Round Up

Immunometabolism in HIV – Immunometabolic defects in colon-resident CD8+ T cells in people with HIV lead to intestinal epithelial apoptosis and disruption of intestinal barrier integrity. (2:50)

T Cell Dysfunction in Tumors – Mitochondria or telomeric reactive oxygen species induce DNA damage responses driving T cell dysfunction. (9:15)

Microglia-Astrocyte Crosstalk – Microglia-derived Wnts drive astrocytes to reduce their association with synapses. (22:00)

Monocyte-Derived Macrophages in Tumors – Researchers identified myeloid progenitor programs that fuel pro-tumorigenic monocyte-derived macrophages. (28:45)

Image courtesy of Dr. Harikesh Wong