Ep. 21: “Trained Immunity” Featuring Dr. Mihai Netea

Guest:

Dr. Mihai Netea is a Professor of Experimental Medicine at Radboud University Nijmegen and a Professor of Immunometabolism at the University of Bonn. He discusses the mechanisms of trained immunity, transmission of immune traits across generations via epigenetics, and how some vaccines can enhance immunity to other pathogens.

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The Immunology Science Round Up

Fc-Mediated Responses to SARS-CoV-2 – mRNA vaccination, but not infection, produced spike antibodies that maintained Fc receptor binding to SARS-CoV-2 variants of concern.

A Nasal Vaccine for Tuberculosis – An adenovirus-vectored tuberculosis vaccine induced airway tissue-resident memory CD4 and CD8 T cells.

Behavioral Immune Landscapes of Inflammation – Researchers used 4D live imaging to obtain behavioral descriptors of individual cells and build behavioral landscapes.

Platelet Aggregation in Sepsis – Scientists showed that inhibiting NFAT in activated mouse and human platelets enhanced their aggregation.

Image courtesy of Dr. Mihai Netea