Ep. 46: “Allergies and the Immune System” Featuring Dr. Caroline Sokol

Guest:

Dr. Caroline Sokol is a Principal Investigator at Massachusetts General Hospital and an Assistant Professor of Medicine at Harvard Medical School. Her lab studies the innate immune control of allergic disease.  She talks about the role of sensory neurons and dendritic cells in allergic responses and insights into allergies from her son’s first bee sting.

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The Immunology Science Round Up

Microbiome Transmission – Researchers identified microbiome transmission patterns from mother to infant and between cohabitating individuals.

Long-Lasting T Cells – By repeatedly immunizing generations of mice, scientists found that functional T cells can proliferate well beyond the lifespan of the organism.

Dietary Cholesterol and Humoral Immune Responses – Researchers revealed tissue-restricted modulation of IgA secretion by plasma cells that is centered around dietary cholesterol metabolites.

γδ T cells in Immunotherapy – γδ T cells contribute to the response to immune checkpoint blockade in patients with cancers with HLA class I defects.

Image courtesy of Dr. Caroline Sokol