Ep. 51: “The Journey of Cells” Featuring Dr. Doug Green

Guest:

Dr. Doug Green is the Peter C. Doherty Endowed Chair of Immunology at St. Jude Children’s Research Hospital. His research focuses on the central mechanisms of cell death, survival, and the immune response. He talks about what happens when cell death fails, the role of Myc, and setting up collaborations in science.

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The Immunology Science Round Up

Gut Bacteria and Social Avoidance – Colonic γδ T cells modulate behavioral vulnerability to chronic social stress via dectin-1 signaling.

Base Editing to Treat Severe Combined Immunodeficiency –  Researchers used an adenine base editing strategy to restore CD3δ in autologous hematopoietic stem and progenitor cells.

FcμR–IgM Interaction – Scientists used crystallography and cryo-electron microscopy to study how FcμR recognizes different forms of IgM to regulate diverse immune responses.

Tissue-Resident Macrophage Differentiation – Researchers analyzed immune cells in the pleural cavity of C57BL/6 and BALB/c mice and found different responses to nematode infection.

Image courtesy of Dr. Doug Green