Ep. 192: “Gene Expression and the Brain” Featuring Dr. Johan Jakobsson

Guest:

Dr. Johan Jakobsson is a Professor of Molecular Neurogenetics at the Lund Stem Cell Center. His research focuses on epigenetic mechanisms of the brain, including the role of microRNAs, long non-coding RNAs, and endogenous retroelements in neural stem cells and neurons.

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The Stem Cell Science Round Up

Intestinal Organoids to Model Self-Organization – Researchers found that stem cell zones in intestinal organoid cultures are shaped by fission events, and that organoid inflation drives stem cell differentiation.

Wound Healing Without Scarring – Preventing Engrailed-1 activation during wound healing promotes skin regeneration with recovery of skin appendages, ultrastructure, and mechanical strength.

Differentiation Unmasks Hidden Aspects of Aging in Stem Cells – Scientists used single-cell RNA sequencing to study age-related changes in muscle stem cells and fibro-adipose progenitors, and found an energy barrier in myogenic differentiation.

Human-Monkey Chimeric Embryos  – Researchers demonstrated that hEPSCs survived, proliferated, and generated several peri- and early post-implantation cell lineages inside monkey embryos.

Photo Reference: Courtesy of Dr. Johan Jakobsson