Ep. 196: “Human Brain Creation” Featuring Dr. Aparna Bhaduri

Guest:

Dr. Aparna Bhaduri is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her lab studies how the human brain is created, with billions of cells spanning hundreds or thousands of cell types. They also explore how the cell building blocks of development can reappear later in life in brain cancers such as glioblastoma.

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The Stem Cell Science Round Up

Hair Thinning in Obesity – Researchers found that obesity-induced stress depletes hair follicle stem cells in mice.

Tracking Keratinocyte Stem Cells – Scientists used deep learning to track the motion of individual keratinocytes and keratinocyte stem cells, allowing them to identify the stem cells in a mixed population and study how culture conditions affect dynamics.

Flipping a Switch in Heart Failure – Researchers identified a transcriptional switch that controls the activation of fibroblasts, and could be used to prevent fibrosis in the heart and other organs.

Mapping Mouse Brain Development – Scientists used single cell sequencing to generate a comprehensive atlas of the developing mouse neocortex.

Photo Reference: Courtesy of Dr. Aparna Bhaduri