Ep. 202: “Regulation of Stem Cells in the Blood” Featuring Dr. Jennifer Trowbridge

Guest:

Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.

Featured Products and Resources:

• Use STEMvision™ for Automated Hematopoietic CFU Assay Imaging & Analysis.
• Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.

The Stem Cell Science Round Up

Reversing Cardiotoxicity from Chemotherapy – Doxorubicin-induced cardiotoxicity in patient-derived cardiomyocytes can be reduced with retinoic acid receptor-γ agonists.

Heart Vascularization in Infant Development – Researchers showed that the embryonic coronary plexus expands through the DLL4–NOTCH1 signaling pathway to vascularize the myocardium.

iPSC-Derived NK Cells for Immunotherapy – Scientists used gene-edited iPSCs to derive natural killer (NK) cells that showed anti-tumor activity in vivo.

Origins of Pancreatic Cancer – Through lineage-tracing, researchers found a link between renewal mechanisms in the exocrine pancreas and initiation of pancreatic carcinogenesis.

Photo Reference: Courtesy of Dr. Jennifer Trowbridge