Ep. 213: “Hematopoietic Stem Cell Biology” Featuring Dr. Kelly McNagny

Guest:

Dr. Kelly McNagny is a Professor of Medical Genetics and Biomedical Engineering at the University of British Columbia. His research program is focused on hematopoietic stem cell biology, specifically in understanding the signaling networks that regulate stem cell differentiation and how these cells interact with their microenvironment. He talks about how hematopoietic stem cell differentiation is related to chronic inflammatory diseases, targeting glycosylation in solid tumors, and his international career path.

Featured Products and Resources:

• Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.
• Make sure your cells are still hematopoietic stem and progenitor cells by using StemSpan SFEM II medium.

The Stem Cell Science Round Up

A Signaling Circuit to Control Cell Population – Researchers engineered mammalian cells with signaling circuits that allow cells to control their own population size.

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes – Scientists used extracellular vesicles to enhance transdifferentiation of fibroblasts into induced cardiomyocyte-like cells.

Modeling Injury and Repair in Kidney Organoids – Researchers identified a drug that mediates kidney repair in a cisplatin-induced injury organoid model.

Infecting Cervical Organoids with HPV and Chlamydia – Chlamydia and HPV co-infection creates a unique cellular microenvironment that may lead to cancer.

Photo Reference: Courtesy of Dr. Kelly McNagny