Ep. 229: “Cellular Reprogramming and Pluripotency” Featuring Dr. Jacob Hanna

Guest:

Dr. Jacob Hanna is an Associate Professor at the Weizmann Institute of Science and investigates cellular reprogramming and embryogenesis. This episode features a discussion on the challenges of growing embryo models in a roller culture system and the feasibility of making human gametes. Dr. Hanna also talks about launching the startup, Renewal Bio, the ethical discussions surrounding stem cell-derived embryos, and creating a more inclusive and equitable scientific community.

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The Stem Cell Science Round Up

Oocytes Store mRNAs around Mitochondria – Researchers discovered that mammalian oocytes store maternal mRNAs around the mitochondria in a membraneless compartment with hydrogel-like properties.

Skeletal Stem/Progenitor Cells in Bone Injury Repair – Different cell types are primarily responsible for repairing different types of bone injuries.

How Glioblastoma Stem Cells Drive Cancer Progression – Glioblastoma stem cell-secreted histamine promotes glioblastoma progression by increasing angiogenesis.

Organogenesis in a Dish – Scientists engineered vascularized, perfusable human enteroids to model innate immune responses in inflammatory bowel disease.

Photo Reference: Courtesy of Dr. Jacob Hanna