Ep. 274: “Brain Organoids” Featuring Dr. Ziyuan Guo

Guest:

Dr. Ziyuan Guo is an Assistant Professor of Pediatrics at the Center for Stem Cell & Organoid Medicine at Cincinnati Children’s Hospital. He talks about in vivo reprogramming and cell and gene therapy in neurodevelopmental and neurodegenerative disorders. He also discusses assembloids to model the blood-brain barrier and strategies for organoid vascularization.

Featured Products and Resources:

• Use STEMdiff Cerebral Organoid Kits to mimic early brain development.
• Get a free wallchart showing how neural organoids are generated and can be used to better understand brain development.

The Stem Cell Science Round Up

Modeling Celiac Disease – Scientists generated air–liquid interface duodenal organoids from celiac disease patients.

Intestinal Immuno-Organoids – Intestinal immuno-organoids can be used to study tissue-resident immune responses in tumorigenesis and other diseases.

Naive PSCs in the Blastocyst – A blastocyst motif substrate reverts mouse and human PSCs to a naive state in vitro.

Sensory Neuron Excitability – Schwann cell-secreted PGE2 promotes neuronal maturation and normal sensory function.

Image courtesy of Dr. Ziyuan Guo