Ep. 283: “Molecular Hematopoiesis” Featuring Dr. Cynthia Dunbar

Guest:

Dr. Cynthia “Cindy” Dunbar is National Institutes of Health (NIH) Distinguished Investigator and Chief of the Translational Stem Cell Biology Branch at the National Heart, Lung, and Blood Institute of the NIH. She talks about using macaques to study hematopoiesis and aging, and the challenges and considerations for using these models. She also discusses her collaborative study transplanting iPSC-derived cardiomyocytes into rhesus macaques, as well as the NIH’s unique research environment and her musical talents outside of the lab.

Featured Products and Resources:

• Cell Quality Attributes of Human Pluripotent Stem Cells
• Free Wallchart: Directed Differentiation of ESCs and iPSCs

The Stem Cell Science Round Up

Enhancers in Neurogenesis – INST10 promotes epigenetic changes and transcription factor binding at enhancers that drive neural cell fate commitment.

Hepatoblastoma Organoids – Researchers studied the molecular and drug sensitivity landscapes of hepatoblastomas and tumor-derived organoids.

Sea Anemone Regeneration – In Nematostella vectensis, local regeneration triggers a systemic homeostatic response, leading to coordinated whole-body remodeling.

iPSC-Derived Human Venous Endothelial Cells – Scientists developed a model of vascular malformations and identified potential drug treatments.

Image courtesy of Dr. Cynthia Dunbar